L-364,373

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Cat.No. 2660 - L-364,373 | C25H20FN3O | CAS No. 103342-82-1
Description: KV7.1 channel activator, activates IKs
Alternative Names: R-L3
Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.

Technical Data

M. Wt 397.44
Formula C25H20FN3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 103342-82-1
PubChem ID 656755
InChI Key CGBANSGENFERAT-JOCHJYFZSA-N
Smiles CN(C1=CC=CC=C1C(C5=CC=CC=C5F)=N[C@@H]2CC3=CNC4=C3C=CC=C4)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 397.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Seebohm et al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941 PMID: 14576198

Jow et al (2006) Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443 PMID: 16945016

Salata et al (1998) A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Am.Soc.Pharmacol.Exp.Ther. 53 220 PMID:

Chadha et al (2012) Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries. Br.J.Pharmacol. 166 1377 PMID: 22251082


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