L-165,041

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Cat.No. 1856 - L-165,041 | C22H26O7 | CAS No. 79558-09-1
Description: Potent PPARδ agonist
Chemical Name: [4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ┬áreceptors over other subtypes. Raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.

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Technical Data

M. Wt 402.44
Formula C22H26O7
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 79558-09-1
PubChem ID 4364841
InChI Key YBEZORYMVISYOA-UHFFFAOYSA-N
Smiles CCCC1=C(O)C(CC=O)=CC=C1OCCCOC1=CC=C(OCC(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 40.24 100
DMSO 40.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 402.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.42 mL 24.85 mL
5 mM 0.5 mL 2.48 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Berger et al (1999) Novel peroxisome proliferator-activated receptor (PPAR)γ and PPARδ ligands produce distinct biological effects. J.Biol.Chem. 274 6718 PMID: 10037770

Iwashita et al (2007) Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo. J.Pharmacol.Exp.Ther. 320 1087 PMID: 17167170

Leibowitz et al (2000) Activation of PPARδ alters lipid metabolism in db/db mice. FEBS Lett. 473 333 PMID: 10818235


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Keywords: Potent PPARδ PPARdelta agonists Peroxisome Proliferator-Activating Receptors agonist L165041 PPARdelta Receptors

1 Citation for L-165,041

Citations are publications that use Tocris products. Selected citations for L-165,041 include:

Mottillo et al (2012) Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) ╬▒ and ╬┤ in brown adipocytes to match fatty acid oxidation with supply. J Mol Graph Model 287 25038 PMID: 22685301


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