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Submit ReviewL-165,041
Description: Potent PPARδ agonist
Chemical Name: [4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid
Purity: ≥98% (HPLC)
Biological Activity for L-165,041
L-165,041 is a potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. Raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.
Compound Libraries for L-165,041
L-165,041 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for L-165,041
| M. Wt | 402.44 |
| Formula | C22H26O7 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 79558-09-1 |
| PubChem ID | 4364841 |
| InChI Key | YBEZORYMVISYOA-UHFFFAOYSA-N |
| Smiles | CCCC1=C(O)C(CC=O)=CC=C1OCCCOC1=CC=C(OCC(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-165,041
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References for L-165,041
References are publications that support the biological activity of the product.
Berger et al (1999) Novel peroxisome proliferator-activated receptor (PPAR)γ and PPARδ ligands produce distinct biological effects. J.Biol.Chem. 274 6718 PMID: 10037770
Iwashita et al (2007) Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo. J.Pharmacol.Exp.Ther. 320 1087 PMID: 17167170
Leibowitz et al (2000) Activation of PPARδ alters lipid metabolism in db/db mice. FEBS Lett. 473 333 PMID: 10818235
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Keywords: L-165,041, L-165,041 supplier, Potent, PPARδ, PPARdelta, agonists, Peroxisome, Proliferator-Activating, Receptors, agonist, L165041, 1856, Tocris Bioscience
2 Citations for L-165,041
Citations are publications that use Tocris products. Selected citations for L-165,041 include:
Mottillo et al (2012) Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply. J Mol Graph Model 287 25038 PMID: 22685301
Martín-Martín et al (2018) PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth. Cancer Res 78 399 PMID: 29187400
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