L-165,041

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Description: Potent PPARδ agonist
Chemical Name: [4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for L-165,041

L-165,041 is a potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. Raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.

Compound Libraries for L-165,041

L-165,041 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-165,041

M. Wt 402.44
Formula C22H26O7
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 79558-09-1
PubChem ID 4364841
InChI Key YBEZORYMVISYOA-UHFFFAOYSA-N
Smiles CCCC1=C(O)C(CC=O)=CC=C1OCCCOC1=CC=C(OCC(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-165,041

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 20.12 50
DMSO 40.24 100

Preparing Stock Solutions for L-165,041

The following data is based on the product molecular weight 402.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.42 mL 24.85 mL
5 mM 0.5 mL 2.48 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets for L-165,041

Certificate of Analysis / Product Datasheet
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References for L-165,041

References are publications that support the biological activity of the product.

Berger et al (1999) Novel peroxisome proliferator-activated receptor (PPAR)γ and PPARδ ligands produce distinct biological effects. J.Biol.Chem. 274 6718 PMID: 10037770

Iwashita et al (2007) Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo. J.Pharmacol.Exp.Ther. 320 1087 PMID: 17167170

Leibowitz et al (2000) Activation of PPARδ alters lipid metabolism in db/db mice. FEBS Lett. 473 333 PMID: 10818235


If you know of a relevant reference for L-165,041, please let us know.

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Keywords: L-165,041, L-165,041 supplier, Potent, PPARδ, PPARdelta, agonists, Peroxisome, Proliferator-Activating, Receptors, agonist, L165041, 1856, Tocris Bioscience

2 Citations for L-165,041

Citations are publications that use Tocris products. Selected citations for L-165,041 include:

Martín-Martín et al (2018) PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth. Cancer Res 78 399 PMID: 29187400

Mottillo et al (2012) Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply. J Mol Graph Model 287 25038 PMID: 22685301


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