Home / Pharmacology / Nuclear Receptors / PPARs / PPARδ / PPARδ Agonists / L-165,041

L-165,041

Cat. No. 1856 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent PPARδ agonist
Chemical Name: [4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for L-165,041

L-165,041 is a potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. Raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.

Compound Libraries for L-165,041

L-165,041 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-165,041

M. Wt 402.44
Formula C22H26O7
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 79558-09-1
PubChem ID 4364841
InChI Key YBEZORYMVISYOA-UHFFFAOYSA-N
Smiles CCCC1=C(O)C(CC=O)=CC=C1OCCCOC1=CC=C(OCC(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-165,041

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 20.12 50
DMSO 40.24 100

Preparing Stock Solutions for L-165,041

The following data is based on the product molecular weight 402.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.42 mL 24.85 mL
5 mM 0.5 mL 2.48 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for L-165,041

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for L-165,041

References are publications that support the biological activity of the product.

Berger et al (1999) Novel peroxisome proliferator-activated receptor (PPAR)γ and PPARδ ligands produce distinct biological effects. J.Biol.Chem. 274 6718 PMID: 10037770

Iwashita et al (2007) Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo. J.Pharmacol.Exp.Ther. 320 1087 PMID: 17167170

Leibowitz et al (2000) Activation of PPARδ alters lipid metabolism in db/db mice. FEBS Lett. 473 333 PMID: 10818235

If you know of a relevant reference for L-165,041, please let us know.

View Related Products by Target

View Related Products by Product Action

View all PPARδ Agonists

Keywords: L-165,041, L-165,041 supplier, Potent, PPARδ, PPARdelta, agonists, Peroxisome, Proliferator-Activating, Receptors, agonist, L165041, 1856, Tocris Bioscience

2 Citations for L-165,041

Citations are publications that use Tocris products. Selected citations for L-165,041 include:

Martín-Martín et al (2018) PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth. Cancer Res 78 399 PMID: 29187400

Mottillo et al (2012) Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply. J Mol Graph Model 287 25038 PMID: 22685301

Do you know of a great paper that uses L-165,041 from Tocris? Please let us know.

Reviews for L-165,041

There are currently no reviews for this product. Be the first to review L-165,041 and earn rewards!

Have you used L-165,041?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors