KRH 3955 hydrochloride

Discontinued Product

KRH 3955 hydrochloride (Cat. No. 6126) has been withdrawn from sale for commercial reasons.
Description: Highly potent CXCR4 antagonist; inhibits HIV-1 replication
Chemical Name: N1-[[4-[[(1H-Imidazol-2-ylmethyl)[(1-methyl-1H-imidazol-2-yl)methyl]amino]methyl]phenyl]methyl]-N1-methyl-N4,N4-dipropyl-1,4-butanediamine trihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for KRH 3955 hydrochloride

KRH 3955 hydrochloride is a highly potent CXCR4 antagonist (IC50 = 0.61 nM). Displays selectivity for CXCR4 over a range of other CXC receptors. Inhibits replication of HIV-1 viruses in human PBMC (EC50 values are 0.33 to 1.4 nM). Supresses HIV-1 infection in mice. Orally bioavailable.

Technical Data for KRH 3955 hydrochloride

M. Wt 589.09
Formula C28H45N7.3HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 2253744-59-9
PubChem ID 137919856
InChI Key KLPOLRXJKIOFIQ-UHFFFAOYSA-N
Smiles CCCN(CCCCN(CC1=CC=C(C=C1)CN(CC2=NC=CN2C)CC3=NC=CN3)C)CCC.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for KRH 3955 hydrochloride

Certificate of Analysis / Product Datasheet
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References for KRH 3955 hydrochloride

References are publications that support the biological activity of the product.

Murakami et al (2009) The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100. Antimicrob.Agents Chemother. 53 2940 PMID: 19451305

Iwasaki et al (2009) Efficient inhibition of SDF-1α-mediated chemotaxis and HIV-1 infection by novel CXCR4 antagonists. Cancer Sci. 100 778 PMID: 19245436

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Citations for KRH 3955 hydrochloride

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Currently there are no citations for KRH 3955 hydrochloride.

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Literature in this Area

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