KRH 3955 hydrochloride

Pricing Availability   Qty
Cat.No. 6126 - KRH 3955 hydrochloride | C28H45N7.3HCl
Description: Highly potent CXCR4 antagonist; inhibits HIV-1 replication
Chemical Name: N1-[[4-[[(1H-Imidazol-2-ylmethyl)[(1-methyl-1H-imidazol-2-yl)methyl]amino]methyl]phenyl]methyl]-N1-methyl-N4,N4-dipropyl-1,4-butanediamine trihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Highly potent CXCR4 antagonist (IC50 = 0.61 nM). Displays selectivity for CXCR4 over a range of other CXC receptors. Inhibits replication of HIV-1 viruses in human PBMC (EC50 values are 0.33 to 1.4 nM). Supresses HIV-1 infection in mice. Orally bioavailable.

Technical Data

M. Wt 589.09
Formula C28H45N7.3HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
Smiles CCCN(CCCCN(CC1=CC=C(C=C1)CN(CC2=NC=CN2C)CC3=NC=CN3)C)CCC.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.91 100
water 58.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 589.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.7 mL 8.49 mL 16.98 mL
5 mM 0.34 mL 1.7 mL 3.4 mL
10 mM 0.17 mL 0.85 mL 1.7 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Murakami et al (2009) The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100. Antimicrob.Agents Chemother. 53 2940 PMID: 19451305

Iwasaki et al (2009) Efficient inhibition of SDF-1α-mediated chemotaxis and HIV-1 infection by novel CXCR4 antagonists. Cancer Sci. 100 778 PMID: 19245436


If you know of a relevant reference for KRH 3955 hydrochloride, please let us know.

View Related Products by Product Action

View all Chemokine CXC Receptor Antagonists

Keywords: KRH 3955 hydrochloride, KRH 3955 hydrochloride supplier, KRH3955, hydrochloride, 675135-77-0, 675137-96-9, 909570-56-5, 1097732-62-1, potent, chemokine, CXC, receptor, 4, inhibitors, inhibits, antagonists, CXCR4, antagonism, HIV-1, antiviral, Chemokine, Receptors, Antivirals, 6126, Tocris Bioscience

Citations for KRH 3955 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for KRH 3955 hydrochloride. Do you know of a great paper that uses KRH 3955 hydrochloride from Tocris? Please let us know.

Reviews for KRH 3955 hydrochloride

There are currently no reviews for this product. Be the first to review KRH 3955 hydrochloride and earn rewards!

Have you used KRH 3955 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation