Kobe 0065

Discontinued Product

Kobe 0065 (Cat. No. 5475) has been withdrawn from sale for commercial reasons.
Description: H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling
Chemical Name: N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide
Datasheet
Citations
Reviews

Biological Activity for Kobe 0065

H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling. Selectively attenuates proliferation and induces apoptosis of cancer cells harboring Ras oncogenes. Reduces growth of K-Ras mutant SW480 colon carcinoma cell xenografts in mice. Orally active.

Technical Data for Kobe 0065

M. Wt 449.79
Formula C15H11ClF3N5O4S
Storage Store at +4°C
CAS Number 436133-68-5
PubChem ID 3827663
InChI Key KSJVAYBCXSURMQ-UHFFFAOYSA-N
Smiles CC1=C(Cl)C=C(NC(NNC2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2[N+]([O-])=O)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Kobe 0065

References are publications that support the biological activity of the product.

Shima et al (2013) In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.U.S.A. 110 8182 PMID: 23630290

View Related Products by Target

Keywords: Kobe 0065, Kobe 0065 supplier, Kobe0065, H-ras-GTP, cRaf, interaction, inhibitors, inhibits, orally, active, Raf, Kinase, 5475, Tocris Bioscience

Citations for Kobe 0065

Citations are publications that use Tocris products.

Currently there are no citations for Kobe 0065.

Reviews for Kobe 0065

There are currently no reviews for this product. Be the first to review Kobe 0065 and earn rewards!

Have you used Kobe 0065?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review