You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling. Selectively attenuates proliferation and induces apoptosis of cancer cells harboring Ras oncogenes. Reduces growth of K-Ras mutant SW480 colon carcinoma cell xenografts in mice. Orally active.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||4.5||10 with gentle warming|
|water||2.25||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 449.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||22.23 mL||111.16 mL||222.33 mL|
|0.5 mM||4.45 mL||22.23 mL||44.47 mL|
|1 mM||2.22 mL||11.12 mL||22.23 mL|
|5 mM||0.44 mL||2.22 mL||4.45 mL|
References are publications that support the biological activity of the product.
Shima et al (2013) In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.U.S.A. 110 8182 PMID: 23630290
If you know of a relevant reference for Kobe 0065, please let us know.
Keywords: Kobe 0065, Kobe 0065 supplier, Kobe0065, H-ras-GTP, cRaf, interaction, inhibitors, inhibits, orally, active, Raf, Kinase, 5475, Tocris Bioscience
Citations for Kobe 0065
Citations are publications that use Tocris products.
Currently there are no citations for Kobe 0065. Do you know of a great paper that uses Kobe 0065 from Tocris? Please let us know.
Reviews for Kobe 0065
There are currently no reviews for this product. Be the first to review Kobe 0065 and earn rewards!
Have you used Kobe 0065?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.