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Biological Activity for Kobe 0065
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling. Selectively attenuates proliferation and induces apoptosis of cancer cells harboring Ras oncogenes. Reduces growth of K-Ras mutant SW480 colon carcinoma cell xenografts in mice. Orally active.
Technical Data for Kobe 0065
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Kobe 0065
References are publications that support the biological activity of the product.
Shima et al (2013) In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.U.S.A. 110 8182 PMID: 23630290
Keywords: Kobe 0065, Kobe 0065 supplier, Kobe0065, H-ras-GTP, cRaf, interaction, inhibitors, inhibits, orally, active, Raf, Kinase, 5475, Tocris Bioscience
Citations for Kobe 0065
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Currently there are no citations for Kobe 0065.
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Literature in this Area
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