Kobe 0065

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Cat.No. 5475 - Kobe 0065 | C15H11ClF3N5O4S | CAS No. 436133-68-5
Description: H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling
Chemical Name: N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide
Literature (3)

Biological Activity

H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling. Selectively attenuates proliferation and induces apoptosis of cancer cells harboring Ras oncogenes. Reduces growth of K-Ras mutant SW480 colon carcinoma cell xenografts in mice. Orally active.

Technical Data

M. Wt 449.79
Formula C15H11ClF3N5O4S
Storage Store at +4°C
CAS Number 436133-68-5
PubChem ID 3827663
Smiles CC1=C(Cl)C=C(NC(NNC2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2[N+]([O-])=O)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 4.5 10 with gentle warming
water 2.25 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 449.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.23 mL 111.16 mL 222.33 mL
0.5 mM 4.45 mL 22.23 mL 44.47 mL
1 mM 2.22 mL 11.12 mL 22.23 mL
5 mM 0.44 mL 2.22 mL 4.45 mL

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References are publications that support the biological activity of the product.

Shima et al (2013) In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.U.S.A. 110 8182 PMID: 23630290

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Keywords: Kobe 0065, Kobe 0065 supplier, Kobe0065, H-ras-GTP, cRaf, interaction, inhibitors, inhibits, orally, active, Raf, Kinase, 5475, Tocris Bioscience

Citations for Kobe 0065

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Literature in this Area

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