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Cat.No. 6664 - Kinesore | C20H16Br2N4O4 | CAS No. 363571-83-9
Description: Kinesin-1 modulator; cell permeable
Chemical Name: 3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Kinesin-1 modulator. Inhibits SKIP-KLC2 interaction, but promotes kinesin-1 function in controlling the organization of the microtubule network. Induces remodeling of the microtubule network and the formation of extensive microtubule-rich projections. Cell permeable.

Technical Data

M. Wt 536.17
Formula C20H16Br2N4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 363571-83-9
PubChem ID 5507411
Smiles CC1=CC(/C=N/NC(C2=CC(Br)=C(C(Br)=C2)O)=O)=C(N1C3=CC([N+]([O-])=O)=CC=C3)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 53.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 536.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.33 mL 18.65 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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References are publications that support the biological activity of the product.

Randall et al (2017) A small-molecule activator of kinesin-1 drives remodeling of the microtubule network. Proc.Natl.Acad.Sci.USA 114 13743 PMID: 29229862

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Keywords: Kinesore, Kinesore supplier, Kinesin-1, modulators, modulates, SKIP-KLC2, microtubule, remodeling, cell, permeable, Kinesin, 6664, Tocris Bioscience

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