You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for KH CB19
Selective, potent inhibitor of CDC2-like kinase (CLK) 1 and 4 (IC50 = 20 nM for CLK1). Suppresses serine/arginine-rich protein phosphorylation by CLKs under proinflammatory conditions. Displays selectivity over a panel of 71 protein kinases. ATP-competitive.
Technical Data for KH CB19
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for KH CB19
References are publications that support the biological activity of the product.
Fedorov et al (2011) Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem.Biol. 18 67 PMID: 21276940
Boltzen et al (2012) Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-α-induced apoptosis. J.Mol.Cell.Cardiol. 52 1056 PMID: 22326437
Eisenreich et al (2013) Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells. Oncol.Rep. 30 462 PMID: 23604472
Knapp et al (2013) A public-private partnership to unlock the untargeted kinome. Nat.Chem.Biol. 9 3 PMID: 23238671
View Related Products by Product Action
Keywords: KH CB19, KH CB19 supplier, KHCB19, CLK1, inhibitors, inhibits, CDC2-like, kinase, CLKs, CLK4, CLK, (Cdc2-like, kinases), 4262, Tocris Bioscience
Citations for KH CB19
Citations are publications that use Tocris products.
Currently there are no citations for KH CB19.
Reviews for KH CB19
There are currently no reviews for this product. Be the first to review KH CB19 and earn rewards!
Have you used KH CB19?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.