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Selective, potent inhibitor of CDC2-like kinase (CLK) 1 and 4 (IC50 = 20 nM for CLK1). Suppresses serine/arginine-rich protein phosphorylation by CLKs under proinflammatory conditions. Displays selectivity over a panel of 71 protein kinases. ATP-competitive.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Fedorov et al (2011) Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem.Biol. 18 67 PMID: 21276940
Boltzen et al (2012) Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-α-induced apoptosis. J.Mol.Cell.Cardiol. 52 1056 PMID: 22326437
Eisenreich et al (2013) Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells. Oncol.Rep. 30 462 PMID: 23604472
Knapp et al (2013) A public-private partnership to unlock the untargeted kinome. Nat.Chem.Biol. 9 3 PMID: 23238671
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Keywords: KH CB19, KH CB19 supplier, KHCB19, CLK1, inhibitors, inhibits, CDC2-like, kinase, CLKs, CLK4, Cdc2-like, kinases, 4262, Tocris Bioscience
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