Discontinued Product

KH CB19 (Cat. No. 4262) has been withdrawn from sale for commercial reasons.
Description: Selective, potent inhibitor of CLK1 and 4
Chemical Name: Ethyl 3-(2-Amino-1-cyanoethenyl)-6,7-dichloro-1-methylindole-2-carboxylate
Purity: ≥97% (HPLC)

Biological Activity for KH CB19

Selective, potent inhibitor of CDC2-like kinase (CLK) 1 and 4 (IC50 = 20 nM for CLK1). Suppresses serine/arginine-rich protein phosphorylation by CLKs under proinflammatory conditions. Displays selectivity over a panel of 71 protein kinases. ATP-competitive.

Technical Data for KH CB19

M. Wt 338.19
Formula C15H13Cl2N3O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1354037-26-5
Smiles ClC1=C(N(C)C(C(OCC)=O)=C2/C(C#N)=C\N)C2=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for KH CB19

Certificate of Analysis / Product Datasheet
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References for KH CB19

References are publications that support the biological activity of the product.

Fedorov et al (2011) Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem.Biol. 18 67 PMID: 21276940

Boltzen et al (2012) Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-α-induced apoptosis. J.Mol.Cell.Cardiol. 52 1056 PMID: 22326437

Eisenreich et al (2013) Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells. Oncol.Rep. 30 462 PMID: 23604472

Knapp et al (2013) A public-private partnership to unlock the untargeted kinome. Nat.Chem.Biol. 9 3 PMID: 23238671

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Keywords: KH CB19, KH CB19 supplier, KHCB19, CLK1, inhibitors, inhibits, CDC2-like, kinase, CLKs, CLK4, CLK, (Cdc2-like, kinases), 4262, Tocris Bioscience

Citations for KH CB19

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Currently there are no citations for KH CB19.

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