Discontinued ProductUnfortunately KH CB19 (Cat. No. 4262) has been withdrawn from sale for commercial reasons.
Selective, potent inhibitor of CDC2-like kinase (CLK) 1 and 4 (IC50 = 20 nM for CLK1). Suppresses serine/arginine-rich protein phosphorylation by CLKs under proinflammatory conditions. Displays selectivity over a panel of 71 protein kinases. ATP-competitive.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 338.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.96 mL||14.78 mL||29.57 mL|
|5 mM||0.59 mL||2.96 mL||5.91 mL|
|10 mM||0.3 mL||1.48 mL||2.96 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
References are publications that support the products' biological activity.
Fedorov et al (2011) Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem.Biol. 18 67 PMID: 21276940
Boltzen et al (2012) Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-α-induced apoptosis. J.Mol.Cell.Cardiol. 52 1056 PMID: 22326437
Eisenreich et al (2013) Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells. Oncol.Rep. 30 462 PMID: 23604472
Knapp et al (2013) A public-private partnership to unlock the untargeted kinome. Nat.Chem.Biol. 9 3 PMID: 23238671
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Keywords: KH CB19, supplier, KHCB19, CLK1, inhibitors, inhibits, CDC2-like, kinase, CLKs, CLK4, Cdc2-like, kinases, Cdc2-like, kinases, Tocris Bioscience
Citations for KH CB19
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Currently there are no citations for KH CB19.
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Literature in this Area
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