Ketotifen fumarate

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Cat.No. 0784 - Ketotifen fumarate | C19H19NOS.C4H4O4 | CAS No. 34580-14-8
Description: H1 antagonist
Chemical Name: 4,9-Dihydro-4-(1-methyl-4-piperidinylidene-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate
Purity: ≥99% (HPLC)

Biological Activity

An H1 receptor antagonist.

Technical Data

M. Wt 425.5
Formula C19H19NOS.C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 34580-14-8
PubChem ID 5282408
Smiles OC(=O)\C=C\C(O)=O.CN1CCC(CC1)=C1C2=C(SC=C2)C(=O)CC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 425.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.24 mL 1.18 mL 2.35 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Abu-Dalu et al (1996) The actions of ketotifen on intestinal smooth muscles. Eur.J.Pharmacol. 309 189 PMID: 8874138

Martin and Römer (1978) The pharmacological properties of a new orally active antianaphylactic compound: ketotifen, a benzocycloheptathiophene. Arzneimittelforschung 28 770 PMID: 35171

Merck Index 5319 PMID:

If you know of a relevant reference for Ketotifen fumarate, please let us know.

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