K 858

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Cat.No. 3703 - K 858 | C13H15N3O2S | CAS No. 72926-24-0
Description: Selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor
Chemical Name: N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM). Induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells. Displays no effect on microtubule dynamics. Preferentially induces mitotic arrest in cancer cells.

Technical Data

M. Wt 277.34
Formula C13H15N3O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 72926-24-0
PubChem ID 2930014
InChI Key JEFVYQYZCAVNTP-UHFFFAOYSA-N
Smiles CC1(C2=CC=CC=C2)N(C(C)=O)N=C(NC(C)=O)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.73 100
ethanol 2.77 10

Preparing Stock Solutions

The following data is based on the product molecular weight 277.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.61 mL 18.03 mL 36.06 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
10 mM 0.36 mL 1.8 mL 3.61 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Nakai et al (2009) K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res. 69 3901 PMID: 19351824


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Keywords: K 858, supplier, mitotic, kinesin, Eg5, inhibitors, inhibits, cytoskeleton, motor, proteins, ATPase, K858, Kinesin, Tocris Bioscience

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

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