Dipeptidyl peptidase IV inhibitor. Inhibits rat, canine, human and monkey enzymes with IC50 values of 3, 5, 8, and 8 nM respectively. Long-acting hypoglycemic agent; attenuates glucose excursion following glucose loading in Zucker fatty rats.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 328.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.04 mL||15.22 mL||30.45 mL|
|5 mM||0.61 mL||3.04 mL||6.09 mL|
|10 mM||0.3 mL||1.52 mL||3.04 mL|
|50 mM||0.06 mL||0.3 mL||0.61 mL|
References are publications that support the products' biological activity.
Takasaki et al (2004) K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent. Eur.J.Pharmacol. 486 335 PMID: 14985056
Takasaki et al (2004) Effects of combination treatment with dipeptidyl peptidase IV inhibitor and sulfonylurea on glucose levels in rats. J.Pharmacol.Sci. 95 291 PMID: 15215655
Takasaki et al (2004) Involvement of the active metabolites in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV. Eur.J.Pharmacol. 505 237 PMID: 15556158
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Keywords: K 579, supplier, Dipeptidyl, peptidase, IV, DPP-IV, inhibitors, inhibits, Peptidase, Proteinases, Proteases, K579, Dipeptidyl, Peptidase, IV, (DPP-IV), Dipeptidyl, Peptidase, IV, (DPP-IV), Tocris Bioscience
1 Citation for K 579
Citations are publications that use Tocris products. Selected citations for K 579 include:
Fujiwara et al (2015) Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration. Arterioscler Thromb Vasc Biol 56 155 PMID: 25759522
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