K 579

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Cat.No. 2790 - K 579 | C17H24N6O | CAS No. 440100-64-1
Description: Dipeptidyl peptidase IV (DPP-IV) inhibitor
Chemical Name: (2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature

Biological Activity

Dipeptidyl peptidase IV inhibitor. Inhibits rat, canine, human and monkey enzymes with IC50 values of 3, 5, 8, and 8 nM respectively. Long-acting hypoglycemic agent; attenuates glucose excursion following glucose loading in Zucker fatty rats.

Technical Data

M. Wt 328.41
Formula C17H24N6O
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 440100-64-1
PubChem ID 9818824
InChI Key JERPHRNGJBSFAP-AWEZNQCLSA-N
Smiles O=C(CNC2(C)CCN(C3=NC=CC=N3)CC2)N1CCC[C@H]1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 16.42 50
DMSO 32.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 328.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.04 mL 15.22 mL 30.45 mL
5 mM 0.61 mL 3.04 mL 6.09 mL
10 mM 0.3 mL 1.52 mL 3.04 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Takasaki et al (2004) K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent. Eur.J.Pharmacol. 486 335 PMID: 14985056

Takasaki et al (2004) Effects of combination treatment with dipeptidyl peptidase IV inhibitor and sulfonylurea on glucose levels in rats. J.Pharmacol.Sci. 95 291 PMID: 15215655

Takasaki et al (2004) Involvement of the active metabolites in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV. Eur.J.Pharmacol. 505 237 PMID: 15556158


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Keywords: K 579, K 579 supplier, Dipeptidyl, peptidase, IV, DPP-IV, inhibitors, inhibits, Peptidase, Proteinases, Proteases, K579, (DPP-IV), 2790, Tocris Bioscience

2 Citations for K 579

Citations are publications that use Tocris products. Selected citations for K 579 include:

Fujiwara et al (2015) Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration. Arterioscler Thromb Vasc Biol 56 155 PMID: 25759522

Inoue et al (2014) Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats. Dig Dis Sci 59 1286 PMID: 24379150


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Reviews for K 579

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Treat ulcers in vivo
By Yasutada Akiba on 01/04/2018
Assay Type: In Vivo
Species: Rat

Oral once a day treatment is useful to treat small intestinal ulcer model in rats, because of long half life due to enterohepatic circulation.

PMID: 24379150

Literature in this Area

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