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K 03861

Cat. No. 6789 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent CDK2 inhibitor
Alternative Names: AUZ 454
Chemical Name: N-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea
Purity: ≥98% (HPLC)
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Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for K 03861

K 03861 is a potent Cdk2 inhibitor (Kd values are 9.7, 15.4, 18.6 and 50 nM at Cdk2 (C118L/A144C), Cdk2 (A144C), Cdk2 (C118L), and Cdk (WT) respectively. Competes with cyclin binding to inhibit Cdk2 kinase activity in vitro.

Compound Libraries for K 03861

K 03861 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for K 03861

M. Wt 501.51
Formula C24H26F3N7O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 853299-07-7
InChI Key PWDLXPJQFNVTNL-UHFFFAOYSA-N
Smiles CN1CCN(CC2=C(C=C(NC(=O)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3)C=C2)C(F)(F)F)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for K 03861

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.08 50
ethanol 50.15 100

Preparing Stock Solutions for K 03861

The following data is based on the product molecular weight 501.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for K 03861

References are publications that support the biological activity of the product.

Song et al (2017) NEUROG1 regulates CDK2 to promote proliferation in otic progenitors Stem Cell Reports 9 1516 PMID: 29033307

Alexander et al (2015) Type II inhibitors targeting Cdk2 ACS.Chem.Biol 10 2116 PMID: 26158339

If you know of a relevant reference for K 03861, please let us know.

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Citations for K 03861

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