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Biological Activity for K 03861
K 03861 is a potent Cdk2 inhibitor (Kd values are 9.7, 15.4, 18.6 and 50 nM at Cdk2 (C118L/A144C), Cdk2 (A144C), Cdk2 (C118L), and Cdk (WT) respectively. Competes with cyclin binding to inhibit Cdk2 kinase activity in vitro.
Technical Data for K 03861
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for K 03861
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for K 03861
The following data is based on the product molecular weight 501.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.99 mL||9.97 mL||19.94 mL|
|5 mM||0.4 mL||1.99 mL||3.99 mL|
|10 mM||0.2 mL||1 mL||1.99 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References for K 03861
References are publications that support the biological activity of the product.
Song et al (2017) NEUROG1 regulates CDK2 to promote proliferation in otic progenitors Stem Cell Reports 9 1516 PMID: 29033307
Alexander et al (2015) Type II inhibitors targeting Cdk2 ACS.Chem.Biol 10 2116 PMID: 26158339
If you know of a relevant reference for K 03861, please let us know.
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Keywords: K 03861, K 03861 supplier, AUZ454, potent, Cdk2, inhibitors, inhibits, cyclin-dependent, protein, kinases, AUZ, 454, Cyclin-dependent, Kinase, CDK1, Subfamily, 6789, Tocris Bioscience
Citations for K 03861
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