K 03861

Pricing Availability   Qty
Cat.No. 6789 - K 03861 | C24H26F3N7O2 | CAS No. 853299-07-7
Description: Potent Cdk2 inhibitor
Alternative Names: AUZ 454
Chemical Name: N-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity

Potent Cdk2 inhibitor (Kd values are 9.7, 15.4, 18.6 and 50 nM at Cdk2 (C118L/A144C), Cdk2 (A144C), Cdk2 (C118L), and Cdk (WT) respectively. Competes with cyclin binding to inhibit Cdk2 kinase activity in vitro.

Technical Data

M. Wt 501.51
Formula C24H26F3N7O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 853299-07-7
Smiles CN1CCN(CC2=C(C=C(NC(=O)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3)C=C2)C(F)(F)F)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.08 50
ethanol 50.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 501.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References are publications that support the biological activity of the product.

Song et al (2017) NEUROG1 regulates CDK2 to promote proliferation in otic progenitors Stem Cell Reports 9 1516 PMID: 29033307

Alexander et al (2015) Type II inhibitors targeting Cdk2 ACS.Chem.Biol 10 2116 PMID: 26158339

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