Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPotent Cdk2 inhibitor (Kd values are 9.7, 15.4, 18.6 and 50 nM at Cdk2 (C118L/A144C), Cdk2 (A144C), Cdk2 (C118L), and Cdk (WT) respectively. Competes with cyclin binding to inhibit Cdk2 kinase activity in vitro.
M. Wt | 501.51 |
Formula | C24H26F3N7O2 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 853299-07-7 |
InChI Key | PWDLXPJQFNVTNL-UHFFFAOYSA-N |
Smiles | CN1CCN(CC2=C(C=C(NC(=O)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3)C=C2)C(F)(F)F)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 25.08 | 50 | |
ethanol | 50.15 | 100 |
The following data is based on the product molecular weight 501.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.99 mL | 9.97 mL | 19.94 mL |
5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
10 mM | 0.2 mL | 1 mL | 1.99 mL |
50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
References are publications that support the biological activity of the product.
Song et al (2017) NEUROG1 regulates CDK2 to promote proliferation in otic progenitors Stem Cell Reports 9 1516 PMID: 29033307
Alexander et al (2015) Type II inhibitors targeting Cdk2 ACS.Chem.Biol 10 2116 PMID: 26158339
If you know of a relevant reference for K 03861, please let us know.
Keywords: K 03861, K 03861 supplier, AUZ454, potent, Cdk2, inhibitors, inhibits, cyclin-dependent, protein, kinases, AUZ, 454, Cyclin-dependent, Kinase, 6789, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for K 03861. Do you know of a great paper that uses K 03861 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review K 03861 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.