JZP 430

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Cat.No. 5844 - JZP 430 | C16H26N4O3S | CAS No. 1672691-74-5
Description: Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Chemical Name: 4-(4-Morpholinyl)-1,2,5-thiadiazol-3-yl N-cyclooctyl-N-methylcarbamate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).

Technical Data

M. Wt 354.47
Formula C16H26N4O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1672691-74-5
PubChem ID 121513897
InChI Key WKSHMJCYWFOADB-UHFFFAOYSA-N
Smiles O=C(N(C)C1CCCCCCC1)OC2=NSN=C2N3CCOCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.72 50
ethanol 7.09 20

Preparing Stock Solutions

The following data is based on the product molecular weight 354.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.21 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Patel et al (2015) Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. Chem.Med.Chem. 10 253 PMID: 25504894


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Citations for JZP 430

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