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Biological Activity for JZP 430
JZP 430 is a potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).
Compound Libraries for JZP 430
Technical Data for JZP 430
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JZP 430
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for JZP 430
The following data is based on the product molecular weight 354.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.64 mL||28.21 mL||56.42 mL|
|2.5 mM||1.13 mL||5.64 mL||11.28 mL|
|5 mM||0.56 mL||2.82 mL||5.64 mL|
|25 mM||0.11 mL||0.56 mL||1.13 mL|
References for JZP 430
References are publications that support the biological activity of the product.
Patel et al (2015) Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. Chem.Med.Chem. 10 253 PMID: 25504894
If you know of a relevant reference for JZP 430, please let us know.
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Citations for JZP 430
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