JZP 430

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Description: Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Chemical Name: 4-(4-Morpholinyl)-1,2,5-thiadiazol-3-yl N-cyclooctyl-N-methylcarbamate
Purity: ≥98% (HPLC)

Biological Activity for JZP 430

JZP 430 is a potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).

Compound Libraries for JZP 430

JZP 430 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JZP 430

M. Wt 354.47
Formula C16H26N4O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1672691-74-5
PubChem ID 121513897

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JZP 430

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.72 50
ethanol 7.09 20

Preparing Stock Solutions for JZP 430

The following data is based on the product molecular weight 354.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.64 mL 28.21 mL 56.42 mL
2.5 mM 1.13 mL 5.64 mL 11.28 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
25 mM 0.11 mL 0.56 mL 1.13 mL

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References for JZP 430

References are publications that support the biological activity of the product.

Patel et al (2015) Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. Chem.Med.Chem. 10 253 PMID: 25504894

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Citations for JZP 430

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