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JZP 430 is a potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).
JZP 430 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 354.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.64 mL||28.21 mL||56.42 mL|
|2.5 mM||1.13 mL||5.64 mL||11.28 mL|
|5 mM||0.56 mL||2.82 mL||5.64 mL|
|25 mM||0.11 mL||0.56 mL||1.13 mL|
References are publications that support the biological activity of the product.
Patel et al (2015) Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. Chem.Med.Chem. 10 253 PMID: 25504894
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