JZP 361

Pricing Availability Delivery Time Qty
Cat.No. 5851 - JZP 361 | C22H20ClN5O | CAS No. 1680193-80-9
Description: Potent and selective reversible MAGL inhibitor
Chemical Name: [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective reversible MAGL inhibitor (IC50 = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50 values are 1.79 and 7.24 μM, respectively). Displays affinity for H1 receptors (pA2 = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM.

Technical Data

M. Wt 405.88
Formula C22H20ClN5O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1680193-80-9
PubChem ID 102596130
InChI Key GAVZCGTYRWKKDV-UHFFFAOYSA-N
Smiles ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCN(C(N5C=NC=N5)=O)CC\4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.59 100
ethanol 8.12 20

Preparing Stock Solutions

The following data is based on the product molecular weight 405.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.32 mL 24.64 mL
5 mM 0.49 mL 2.46 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Patel et al (2015) Loratadine analogues as MAGL inhibitors. Bioorg.Med.Chem.Lett. 25 1436 PMID: 25752982


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Keywords: JZP 361, supplier, Potent, selective, reversible, MAGL, inhibitors, inhibits, H1, histamine, receptors, MAGL, MAGL, Tocris Bioscience

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