JX 06

Pricing Availability Delivery Time Qty
Cat.No. 5845 - JX 06 | C10H16N2O2S4 | CAS No. 729-46-4
Description: Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor
Chemical Name: Bis(morpholinothiocarbonyl) disulfide
Purity: ≥98% (HPLC)
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Citations
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Literature

Biological Activity

Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro. Reduces tumor volume of A549 xenografts in mice.

Technical Data

M. Wt 324.51
Formula C10H16N2O2S4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 729-46-4
PubChem ID 12892
InChI Key KKVYOWPPMNSLCP-UHFFFAOYSA-N
Smiles S=C(SSC(N1CCOCC1)=S)N2CCOCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 324.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.82 mL
5 mM 0.62 mL 3.08 mL 6.16 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sun et al (2015) JX06 selectively inhibits pyruvate dehydrogenase kinase PDK1 by a covalent cysteine modification. Cancer Res. 75 4923 PMID: 26483203


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Keywords: JX 06, supplier, NSC402538, JX06, potent, selective, PDK1, PDK2, PDK3, pyruvate, dehydrogenase, kinases, inhibitors, inhibits, Other, Kinases, Other, Kinases, Tocris Bioscience

Citations for JX 06

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