JW 67

Discontinued Product

JW 67 (Cat. No. 4651) has been withdrawn from sale for commercial reasons.
Description: Wnt pathway inhibitor; induces degradation of active β-catenin
Chemical Name: Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione
Purity: ≥97% (HPLC)
Reviews (1)
Pathways (1)

Biological Activity for JW 67

JW 67 is an inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8 μM).

Compound Libraries for JW 67

JW 67 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for JW 67

M. Wt 394.38
Formula C21H18N2O6
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 442644-28-2
PubChem ID 644733
Smiles O=C1NC6=C(C=CC=C6)C21OCC3(COC(C(NC5=C4C=CC=C5)=O)4OC3)CO2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for JW 67

References are publications that support the biological activity of the product.

Shultz et al (2012) [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J.Med.Chem. 55 1127 PMID: 22260203

Waaler et al (2011) Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 71 197 PMID: 21199802

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Keywords: JW 67, JW 67 supplier, JW67, canonical, Wnt, pathway, signaling, inhibitors, inhibits, beta, b, β, catenin, proliferation, selective, Other, Signaling, Beta-catenin, 4651, Tocris Bioscience

Citations for JW 67

Citations are publications that use Tocris products.

Currently there are no citations for JW 67.

Reviews for JW 67

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Induces beta-Catenin degradation.
By Anonymous on 02/10/2023
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HepG2, and Huh,

When treated in to hepatoma cells (0.5uM) for 48 hours, it substantially induced the degradation of b catenin.

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Pathways for JW 67

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.