Home / Pharmacology / Enzymes / Polymerases / Tankyrase / Tankyrase Inhibitors / JW 55

JW 55

Cat. No. 4514 2 Citations Submit a Review Datasheet / COA / SDS
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Description: Tankyrase inhibitor
Chemical Name: N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for JW 55

JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.

External Portal Information for JW 55

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of JW55 is reviewed on the chemical probes website.

Compound Libraries for JW 55

JW 55 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JW 55

M. Wt 434.48
Formula C25H26N2O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 664993-53-7
PubChem ID 2946601
InChI Key ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
Smiles O=C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)C1=CC=C(NC(C4=CC=CO4)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JW 55

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.45 100
ethanol 43.45 100

Preparing Stock Solutions for JW 55

The following data is based on the product molecular weight 434.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for JW 55

References are publications that support the biological activity of the product.

Waaler et al (2012) A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 72 2822 PMID: 22440753

If you know of a relevant reference for JW 55, please let us know.

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Keywords: JW 55, JW 55 supplier, JW55, wnt, signaling, inhibitors, inhibits, tankyrase, tnks1/2, tnks1, tnks2, beta-catenin, β-catenin, b-catenin, Poly(ADP-ribose), Polymerase, Tankyrase, 4514, Tocris Bioscience

2 Citations for JW 55

Citations are publications that use Tocris products. Selected citations for JW 55 include:

Hong et al (2015) β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells. Cancer Res 75 656 PMID: 25568183

Okamoto et al (2018) MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs. Oncotarget 9 35844 PMID: 30533199

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