JW 55

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Cat.No. 4514 - JW 55 | C25H26N2O5 | CAS No. 664993-53-7
Description: Tankyrase inhibitor
Chemical Name: N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of JW55 is reviewed on the chemical probes website.

Compound Libraries

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Technical Data

M. Wt 434.48
Formula C25H26N2O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 664993-53-7
PubChem ID 2946601
InChI Key ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
Smiles O=C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)C1=CC=C(NC(C4=CC=CO4)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.45 100
ethanol 43.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 434.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Waaler et al (2012) A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 72 2822 PMID: 22440753


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Keywords: JW 55, JW 55 supplier, JW55, wnt, signaling, inhibitors, inhibits, tankyrase, tnks1/2, tnks1, tnks2, beta-catenin, β-catenin, b-catenin, Poly(ADP-ribose), Polymerase, Tankyrase, 4514, Tocris Bioscience

1 Citation for JW 55

Citations are publications that use Tocris products. Selected citations for JW 55 include:

Hong et al (2015) β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells. Cancer Res 75 656 PMID: 25568183


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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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