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Biological Activity for JNJ 7777120
JNJ 7777120 is a histamine H4 receptor antagonist; displays high affinity (Ki = 4.5 nM) and is >1000-fold selective for H4 over other histamine receptors.
Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.
Compound Libraries for JNJ 7777120
Technical Data for JNJ 7777120
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JNJ 7777120
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for JNJ 7777120
The following data is based on the product molecular weight 277.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.6 mL||18 mL||36 mL|
|5 mM||0.72 mL||3.6 mL||7.2 mL|
|10 mM||0.36 mL||1.8 mL||3.6 mL|
|50 mM||0.07 mL||0.36 mL||0.72 mL|
References for JNJ 7777120
References are publications that support the biological activity of the product.
Jablanowski et al (2003) The first potent and selective non-imidazole human histamine H4 receptor antagonists. J.Med.Chem. 46 3957 PMID: 12954048
Thurmond et al (2004) A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J.Pharmacol.Exp.Ther. 309 404 PMID: 14722321
Strakhova et al (2009) In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Br.J.Pharmacol. 157 44 PMID: 19413570
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Citations for JNJ 7777120
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