JNJ 7777120

Pricing Availability   Qty
Description: Selective H4 antagonist
Chemical Name: 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine
Purity: ≥98% (HPLC)
Citations (2)
Literature (1)

Biological Activity for JNJ 7777120

JNJ 7777120 is a histamine H4 receptor antagonist; displays high affinity (Ki = 4.5 nM) and is >1000-fold selective for H4 over other histamine receptors.

Licensing Information

Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

Compound Libraries for JNJ 7777120

JNJ 7777120 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 7777120

M. Wt 277.75
Formula C14H16ClN3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 459168-41-3
PubChem ID 4908365
Smiles ClC1=CC=C(NC(C(N3CCN(C)CC3)=O)=C2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JNJ 7777120

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 27.77 100
DMSO 13.89 50

Preparing Stock Solutions for JNJ 7777120

The following data is based on the product molecular weight 277.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.6 mL 18 mL 36 mL
5 mM 0.72 mL 3.6 mL 7.2 mL
10 mM 0.36 mL 1.8 mL 3.6 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets for JNJ 7777120

Certificate of Analysis / Product Datasheet
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References for JNJ 7777120

References are publications that support the biological activity of the product.

Jablanowski et al (2003) The first potent and selective non-imidazole human histamine H4 receptor antagonists. J.Med.Chem. 46 3957 PMID: 12954048

Thurmond et al (2004) A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J.Pharmacol.Exp.Ther. 309 404 PMID: 14722321

Strakhova et al (2009) In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Br.J.Pharmacol. 157 44 PMID: 19413570

If you know of a relevant reference for JNJ 7777120, please let us know.

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Keywords: JNJ 7777120, JNJ 7777120 supplier, JNJ7777120, histamine, 4, histaminergic, H4, receptors, antagonists, selective, Histamine, Receptors, 4021, Tocris Bioscience

2 Citations for JNJ 7777120

Citations are publications that use Tocris products. Selected citations for JNJ 7777120 include:

Fang et al (2019) Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch. Immunity 50 1163-1171.e5 PMID: 31027996

David et al (2020) Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth. Elife 9 PMID: 31931959

Do you know of a great paper that uses JNJ 7777120 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.