JNJ 39758979 dihydrochlorideNew
High affinity and selective histamine H4 antagonist (Ki = 12.5 nM). Exhibits >80-fold selectivity for H4 over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.
Sold with the permission of Janssen Pharmaceutica N.V.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 294.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.4 mL||16.99 mL||33.99 mL|
|5 mM||0.68 mL||3.4 mL||6.8 mL|
|10 mM||0.34 mL||1.7 mL||3.4 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
References are publications that support the biological activity of the product.
Thurmond et al (2014) Clinical and preclinical characterization of the histamine H4 receptor antagonist JNJ-39758979. J.Pharmacol.Exp.Ther. 349 176 PMID: 24549371
If you know of a relevant reference for JNJ 39758979 dihydrochloride, please let us know.
View Related Products by Product Action
Keywords: JNJ 39758979 dihydrochloride, JNJ 39758979 dihydrochloride supplier, JNJ39758979, 2HCl, 1046447-90-8, high, affinity, selective, histamine, H4, antagonists, antagonism, anti-inflammatory, orally, bioavailable, Histamine, Receptors, 6279, Tocris Bioscience
Citations for JNJ 39758979 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for JNJ 39758979 dihydrochloride. Do you know of a great paper that uses JNJ 39758979 dihydrochloride from Tocris? Please let us know.
Reviews for JNJ 39758979 dihydrochloride
There are currently no reviews for this product. Be the first to review JNJ 39758979 dihydrochloride and earn rewards!
Have you used JNJ 39758979 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.