JNJ 39758979 dihydrochloride

Pricing Availability   Qty
Cat.No. 6279 - JNJ 39758979 dihydrochloride | C11H19N5.2HCl
Description: High affinity and selective histamine H4 receptor antagonist; orally bioavailable
Chemical Name: 4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity and selective histamine H4 antagonist (Ki = 12.5 nM). Exhibits >80-fold selectivity for H4 over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.

Licensing Information

Sold with the permission of Janssen Pharmaceutica N.V.

Technical Data

M. Wt 294.22
Formula C11H19N5.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 129628806
InChI Key KXPWYAVIFCXPRW-YCBDHFTFSA-N
Smiles CC(C1=CC(N2CC[C@H](C2)N)=NC(N)=N1)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.13 100
DMSO 22.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 294.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 16.99 mL 33.99 mL
5 mM 0.68 mL 3.4 mL 6.8 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Thurmond et al (2014) Clinical and preclinical characterization of the histamine H4 receptor antagonist JNJ-39758979. J.Pharmacol.Exp.Ther. 349 176 PMID: 24549371


If you know of a relevant reference for JNJ 39758979 dihydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Histamine H4 Receptor Antagonists

Keywords: JNJ 39758979 dihydrochloride, JNJ 39758979 dihydrochloride supplier, JNJ39758979, 2HCl, 1046447-90-8, high, affinity, selective, histamine, H4, antagonists, antagonism, anti-inflammatory, orally, bioavailable, Histamine, Receptors, 6279, Tocris Bioscience

Citations for JNJ 39758979 dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for JNJ 39758979 dihydrochloride. Do you know of a great paper that uses JNJ 39758979 dihydrochloride from Tocris? Please let us know.

Reviews for JNJ 39758979 dihydrochloride

There are currently no reviews for this product. Be the first to review JNJ 39758979 dihydrochloride and earn rewards!

Have you used JNJ 39758979 dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Histamine Receptors

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.

Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.