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JNJ 39758979 dihydrochloride New
High affinity and selective histamine H4 antagonist (Ki = 12.5 nM). Exhibits >80-fold selectivity for H4 over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.
Sold with the permission of Janssen Pharmaceutica N.V.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 294.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.4 mL||16.99 mL||33.99 mL|
|5 mM||0.68 mL||3.4 mL||6.8 mL|
|10 mM||0.34 mL||1.7 mL||3.4 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
References are publications that support the biological activity of the product.
Thurmond et al (2014) Clinical and preclinical characterization of the histamine H4 receptor antagonist JNJ-39758979. J.Pharmacol.Exp.Ther. 349 176 PMID: 24549371
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