Selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 12 nM). Brain penetrant and active in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 365.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.74 mL||13.68 mL||27.36 mL|
|5 mM||0.55 mL||2.74 mL||5.47 mL|
|10 mM||0.27 mL||1.37 mL||2.74 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Keith et al (2008) Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amid hydrolase. Bioorg.Med.Chem.Lett. 18 4838 PMID: 18693015
If you know of a relevant reference for JNJ 1661010, please let us know.
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Keywords: Selective reversible FAAH inhibitors inhibits Anandamide Amidase Fatty Acid Amide Hydrolases JNJ1661010 Fatty Acid Amide Hydrolase (FAAH)
2 Citations for JNJ 1661010
Citations are publications that use Tocris products. Selected citations for JNJ 1661010 include:
Brown et al (2010) Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis 31 1584 PMID: 20660502
Stone et al (2012) The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. Br J Pharmacol 165 2758 PMID: 22029844
Do you know of a great paper that uses JNJ 1661010 from Tocris? If so please let us know.
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