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Biological Activity for JNJ 1661010
JNJ 1661010 is a selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 12 nM). Brain penetrant and active in vivo.
Technical Data for JNJ 1661010
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JNJ 1661010
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for JNJ 1661010
The following data is based on the product molecular weight 365.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.74 mL||13.68 mL||27.36 mL|
|5 mM||0.55 mL||2.74 mL||5.47 mL|
|10 mM||0.27 mL||1.37 mL||2.74 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References for JNJ 1661010
References are publications that support the biological activity of the product.
Keith et al (2008) Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amid hydrolase. Bioorg.Med.Chem.Lett. 18 4838 PMID: 18693015
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Keywords: JNJ 1661010, JNJ 1661010 supplier, Selective, reversible, FAAH, inhibitors, inhibits, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, JNJ1661010, Hydrolase, (FAAH), Other, Cannabinoids, 3262, Tocris Bioscience
2 Citations for JNJ 1661010
Citations are publications that use Tocris products. Selected citations for JNJ 1661010 include:
Stone et al (2012) The cytoprotective effects of oleoylethanolamide in Ins-Secr.g cells do not require activation of GPR119. Br J Pharmacol 165 2758 PMID: 22029844
Brown et al (2010) Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis 31 1584 PMID: 20660502
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.