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Submit ReviewJNJ 1661010
Description: Selective, reversible FAAH inhibitor
Chemical Name: N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
Purity: ≥99% (HPLC)
Biological Activity for JNJ 1661010
JNJ 1661010 is a selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 12 nM). Brain penetrant and active in vivo.
Technical Data for JNJ 1661010
| M. Wt | 365.45 |
| Formula | C19H19N5OS |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 681136-29-8 |
| PubChem ID | 2809273 |
| InChI Key | BHBOSTKQCZEAJM-UHFFFAOYSA-N |
| Smiles | O=C(NC3=CC=CC=C3)N1CCN(C2=NC(C4=CC=CC=C4)=NS2)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JNJ 1661010
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.55 | 100 | |
| ethanol | 3.65 | 10 |
Preparing Stock Solutions for JNJ 1661010
The following data is based on the product molecular weight 365.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.68 mL | 27.36 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.47 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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Product Datasheets for JNJ 1661010
References for JNJ 1661010
References are publications that support the biological activity of the product.
Keith et al (2008) Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amid hydrolase. Bioorg.Med.Chem.Lett. 18 4838 PMID: 18693015
If you know of a relevant reference for JNJ 1661010, please let us know.
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Keywords: JNJ 1661010, JNJ 1661010 supplier, Selective, reversible, FAAH, inhibitors, inhibits, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, JNJ1661010, Hydrolase, (FAAH), Other, Cannabinoids, 3262, Tocris Bioscience
2 Citations for JNJ 1661010
Citations are publications that use Tocris products. Selected citations for JNJ 1661010 include:
Stone et al (2012) The cytoprotective effects of oleoylethanolamide in Ins-Secr.g cells do not require activation of GPR119. Br J Pharmacol 165 2758 PMID: 22029844
Brown et al (2010) Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis 31 1584 PMID: 20660502
Do you know of a great paper that uses JNJ 1661010 from Tocris? Please let us know.
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