JNJ 1661010

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Cat.No. 3262 - JNJ 1661010 | C19H19N5OS | CAS No. 681136-29-8
Description: Selective, reversible FAAH inhibitor
Chemical Name: N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 12 nM). Brain penetrant and active in vivo.

Compound Libraries

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Technical Data

M. Wt 365.45
Formula C19H19N5OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 681136-29-8
PubChem ID 2809273
InChI Key BHBOSTKQCZEAJM-UHFFFAOYSA-N
Smiles O=C(NC3=CC=CC=C3)N1CCN(C2=NC(C4=CC=CC=C4)=NS2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.55 100
ethanol 3.65 10

Preparing Stock Solutions

The following data is based on the product molecular weight 365.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.68 mL 27.36 mL
5 mM 0.55 mL 2.74 mL 5.47 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Keith et al (2008) Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amid hydrolase. Bioorg.Med.Chem.Lett. 18 4838 PMID: 18693015


If you know of a relevant reference for JNJ 1661010, please let us know.

View Related Products by Product Action

View all Fatty Acid Amide Hydrolase Inhibitors

Keywords: Selective reversible FAAH inhibitors inhibits Anandamide Amidase Fatty Acid Amide Hydrolases JNJ1661010 Fatty Acid Amide Hydrolase (FAAH)

2 Citations for JNJ 1661010

Citations are publications that use Tocris products. Selected citations for JNJ 1661010 include:

Brown et al (2010) Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis 31 1584 PMID: 20660502

Stone et al (2012) The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. Br J Pharmacol 165 2758 PMID: 22029844


Do you know of a great paper that uses JNJ 1661010 from Tocris? If so please let us know.

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