Home / Pharmacology / Enzymes / Hydrolases / Fatty Acid Amide Hydrolase / Fatty Acid Amide Hydrolase Inhibitors / JNJ 1661010

JNJ 1661010

Cat. No. 3262 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective, reversible FAAH inhibitor
Chemical Name: N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for JNJ 1661010

JNJ 1661010 is a selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 12 nM). Brain penetrant and active in vivo.

Technical Data for JNJ 1661010

M. Wt 365.45
Formula C19H19N5OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 681136-29-8
PubChem ID 2809273
InChI Key BHBOSTKQCZEAJM-UHFFFAOYSA-N
Smiles O=C(NC3=CC=CC=C3)N1CCN(C2=NC(C4=CC=CC=C4)=NS2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JNJ 1661010

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.55 100
ethanol 3.65 10

Preparing Stock Solutions for JNJ 1661010

The following data is based on the product molecular weight 365.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.68 mL 27.36 mL
5 mM 0.55 mL 2.74 mL 5.47 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for JNJ 1661010

References are publications that support the biological activity of the product.

Keith et al (2008) Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amid hydrolase. Bioorg.Med.Chem.Lett. 18 4838 PMID: 18693015

If you know of a relevant reference for JNJ 1661010, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Fatty Acid Amide Hydrolase Inhibitors

Keywords: JNJ 1661010, JNJ 1661010 supplier, Selective, reversible, FAAH, inhibitors, inhibits, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, JNJ1661010, Hydrolase, (FAAH), Other, Cannabinoids, 3262, Tocris Bioscience

2 Citations for JNJ 1661010

Citations are publications that use Tocris products. Selected citations for JNJ 1661010 include:

Stone et al (2012) The cytoprotective effects of oleoylethanolamide in Ins-Secr.g cells do not require activation of GPR119. Br J Pharmacol 165 2758 PMID: 22029844

Brown et al (2010) Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis 31 1584 PMID: 20660502

Do you know of a great paper that uses JNJ 1661010 from Tocris? Please let us know.

Reviews for JNJ 1661010

There are currently no reviews for this product. Be the first to review JNJ 1661010 and earn rewards!

Have you used JNJ 1661010?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.