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JK 184

Cat. No. 3341 1 Citation Submit a Review Datasheet / COA / SDS
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Cat.No. 3341 - JK 184 | C19H18N4OS | CAS No. 315703-52-7
Description: Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway
Chemical Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.

Compound Libraries

JK 184 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 350.44
Formula C19H18N4OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 315703-52-7
PubChem ID 1069686
InChI Key ROYXIPOUVGDTAO-UHFFFAOYSA-N
Smiles CC2=C(C3=CSC(NC4=CC=C(OCC)C=C4)=N3)N1C=CC=CC1=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.04 100
ethanol 8.76 25

Preparing Stock Solutions

The following data is based on the product molecular weight 350.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.27 mL 28.54 mL
5 mM 0.57 mL 2.85 mL 5.71 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Lee et al (2007) A small-molecule antagonist of the hedgehog signaling pathway. Chembiochem. 8 1916 PMID: 17886323

Cupido et al (2009) The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling. Angew.Chem.Int.Ed.Engl. 48 2321 PMID: 19222062

If you know of a relevant reference for JK 184, please let us know.

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1 Citation for JK 184

Citations are publications that use Tocris products. Selected citations for JK 184 include:

Oladapo (2017) Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett 411 136 PMID: 28965853

Do you know of a great paper that uses JK 184 from Tocris? Please let us know.

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