JK 184
Biological Activity
Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.
Compound Libraries
JK 184 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 350.44 |
| Formula | C19H18N4OS |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 315703-52-7 |
| PubChem ID | 1069686 |
| InChI Key | ROYXIPOUVGDTAO-UHFFFAOYSA-N |
| Smiles | CC2=C(C3=CSC(NC4=CC=C(OCC)C=C4)=N3)N1C=CC=CC1=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.04 | 100 | |
| ethanol | 8.76 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 350.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.27 mL | 28.54 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.71 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lee et al (2007) A small-molecule antagonist of the hedgehog signaling pathway. Chembiochem. 8 1916 PMID: 17886323
Cupido et al (2009) The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling. Angew.Chem.Int.Ed.Engl. 48 2321 PMID: 19222062
If you know of a relevant reference for JK 184, please let us know.
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Keywords: JK 184, supplier, Alcohol, dehydrogenase, 7, inhibitors, inhibits, downstream, Hh, signaling, pathway, Signalling, Hedgehog, Gli, JK184, stem, cells, Alcohol, Dehydrogenase, Tocris Bioscience
Citations for JK 184
Citations are publications that use Tocris products.
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Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
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- Nuclear Receptors
- Transporters
- Apoptosis
- Cell Metabolism
- Epigenetics
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- Signal Transduction
- Stem Cells
