JK 184

Discontinued Product

JK 184 (Cat. No. 3341) has been withdrawn from sale for commercial reasons.
Cat.No. 3341 - JK 184 | C19H18N4OS | CAS No. 315703-52-7
Description: Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway
Chemical Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for JK 184

JK 184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.

Technical Data for JK 184

M. Wt 350.44
Formula C19H18N4OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 315703-52-7
PubChem ID 1069686
InChI Key ROYXIPOUVGDTAO-UHFFFAOYSA-N
Smiles CC2=C(C3=CSC(NC4=CC=C(OCC)C=C4)=N3)N1C=CC=CC1=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for JK 184

References are publications that support the biological activity of the product.

Lee et al (2007) A small-molecule antagonist of the hedgehog signaling pathway. Chembiochem. 8 1916 PMID: 17886323

Cupido et al (2009) The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling. Angew.Chem.Int.Ed.Engl. 48 2321 PMID: 19222062

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Keywords: JK 184, JK 184 supplier, Alcohol, dehydrogenase, 7, inhibitors, inhibits, downstream, Hh, signaling, pathway, Signalling, Hedgehog, Gli, JK184, stem, cells, Signaling, Dehydrogenase, Stem, Cell, 3341, Tocris Bioscience

1 Citation for JK 184

Citations are publications that use Tocris products. Selected citations for JK 184 include:

Oladapo (2017) Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett 411 136 PMID: 28965853


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