JJKK 048

Pricing Availability   Qty
Description: Potent and selective MAGL inhibitor
Chemical Name: 4-[Bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl]-1H-1,2,4-triazol-1-yl-methanone
Purity: ≥98% (HPLC)
Citations (1)
Literature (4)

Biological Activity for JJKK 048

JJKK 048 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC50 = 0.4 nM). Exhibits >13,000 and ~630-fold selectivity for MAGL over FAAH and ABHD6, respectively. Increases brain levels of 2-arachidonoylglycerol (2-AG) levels in mice in vivo. Promotes analgesia in pain models.

Compound Libraries for JJKK 048

JJKK 048 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JJKK 048

M. Wt 434.44
Formula C23H22N4O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1515855-97-6
PubChem ID 76313567
Smiles O=C(N6C=NC=N6)N(CC5)CCC5C(C2=CC=C(OCO3)C3=C2)C1=CC(OCO4)=C4C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JJKK 048

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.44 100

Preparing Stock Solutions for JJKK 048

The following data is based on the product molecular weight 434.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for JJKK 048

References are publications that support the biological activity of the product.

Aaltonen et al (2013) Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem.Biol. 20 379 PMID: 23521796

Laitinen et al (2014) Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. Mol.Pharmacol. 85 510 PMID: 24368842

Aaltonen et al (2016) In vivo characterization of the ultrapotent monoacylglycerol lipaseiInhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048). J.Pharmacol.Exp.Ther. 359 62 PMID: 27451409

If you know of a relevant reference for JJKK 048, please let us know.

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Keywords: JJKK 048, JJKK 048 supplier, JJKK048, potent, selective, MAGL, inhibitors, inhibits, monoacylglycerol, lipases, hydrolases, analgesic, analgesia, 5206, Tocris Bioscience

1 Citation for JJKK 048

Citations are publications that use Tocris products. Selected citations for JJKK 048 include:

Dandan et al (2017) Regulatory role of tumor necrosis factor receptor-associated factor 6 in breast cancer by activating the protein kinase B/glycogen synthase kinase 3β signaling pathway. Mol Med Rep 16 2269-2273 PMID: 28627683

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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