Positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).
This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b. Deuterated analog also available.
|Formula||C48H74O14 (B1a form)|
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 50 mM in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 875.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.14 mL||5.71 mL||11.43 mL|
|5 mM||0.23 mL||1.14 mL||2.29 mL|
|10 mM||0.11 mL||0.57 mL||1.14 mL|
|50 mM||0.02 mL||0.11 mL||0.23 mL|
References are publications that support the products' biological activity.
Adelsberger et al (2000) Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide ivermectin. Eur.J.Pharmacol. 394 163 PMID: 10771281
Khakh et al (1999) Allosteric control of gating and kinetics at P2X4 receptor channels. J.Neurosci. 19 7289 PMID: 10460235
Krause et al (1998) Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol.Pharmacol. 53 283 PMID: 9463487
Shan et al (2001) Ivermectin, an unconventional agonist of the glycine receptor chloride channel. J.Biol.Chem. 276 12556 PMID: 11278873
If you know of a relevant reference for Ivermectin, please let us know.
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Keywords: Ivermectin, supplier, Allosteric, modulators, α7, alpha7, nicotinic, receptors, Positive, allosteric, P2X4, Acetylcholine, nAChR, Purinergic, purinoceptors, P2X, Receptors, Nicotinic, (a7), Receptors, Nicotinic, (a7), Receptors, Tocris Bioscience
2 Citations for Ivermectin
Citations are publications that use Tocris products. Selected citations for Ivermectin include:
Ren et al (2016) A biofidelic 3D culture model to study the development of brain cellular systems. Pharmacol Res Perspect 6 24953 PMID: 27112667
Nörenberg et al (2012) Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br J Pharmacol 167 48 PMID: 22506590
Do you know of a great paper that uses Ivermectin from Tocris? If so please let us know.
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