Pricing Availability Delivery Time Qty
Cat.No. 1260 - Ivermectin | C48H74O14 (B1a form) | CAS No. 70288-86-7
Description: Allosteric modulator of α7 nicotinic receptors
Chemical Name: 22,23-Dihydroavermectin B1
Purity: ≥96% (HPLC)
Citations (2)

Biological Activity

Positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).

Technical Data

M. Wt 875.1
Formula C48H74O14 (B1a form)
Storage Desiccate at +4°C
Purity ≥96% (HPLC)
CAS Number 70288-86-7
PubChem ID 6321424
Smiles O[C@H]1[C@H](C)O[C@](O[C@H]2[C@@H](O[C@](O[C@H](/C(C)=C/C[C@@]4([H])O[C@@]7(CC[C@H](C)[C@@]([H])([C@]([H])(C)C)O7)C[C@@H]6C4)[C@@H](C)/C=C/C=C3/[C@]5(O)[C@]([C@H](O)C(C)=CC5C(O6)=O)([H])OC3)([H])C[C@@H]2OC)C)([H])C[C@@H]1OC.O[C@H]8[C@H](C)O[C@](O[C@H]9[C@@H](O[C@](O[C@H](/C(C)=C/C[C@@]%11([H])O[C@@]%14(CC[C@H](C)[C@@]([H])([C@]([H])(C)CC)O%14)C[C@@H]%13C%11)[C@@H](C)/C=C/C=C%10/[C@]%12(O)[C@]([C@H](O)C(C)=CC%12C(O%13)=O)([H])OC%10)([H])C[C@@H]9OC)C)([H])C[C@@H]8OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 50 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 875.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.14 mL 5.71 mL 11.43 mL
5 mM 0.23 mL 1.14 mL 2.29 mL
10 mM 0.11 mL 0.57 mL 1.14 mL
50 mM 0.02 mL 0.11 mL 0.23 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Adelsberger et al (2000) Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide ivermectin. Eur.J.Pharmacol. 394 163 PMID: 10771281

Khakh et al (1999) Allosteric control of gating and kinetics at P2X4 receptor channels. J.Neurosci. 19 7289 PMID: 10460235

Krause et al (1998) Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol.Pharmacol. 53 283 PMID: 9463487

Shan et al (2001) Ivermectin, an unconventional agonist of the glycine receptor chloride channel. J.Biol.Chem. 276 12556 PMID: 11278873

Merck Index 12 5264 PMID:

If you know of a relevant reference for Ivermectin, please let us know.

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View all Nicotinic (α7) Receptor Modulators

Keywords: Ivermectin, supplier, Allosteric, modulators, α7, alpha7, nicotinic, receptors, Positive, allosteric, P2X4, Acetylcholine, nAChR, Purinergic, purinoceptors, P2X, Receptors, Nicotinic, (a7), Receptors, Nicotinic, (a7), Receptors, Tocris Bioscience

2 Citations for Ivermectin

Citations are publications that use Tocris products. Selected citations for Ivermectin include:

Nörenberg et al (2012) Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br J Pharmacol 167 48 PMID: 22506590

Ren et al (2016) A biofidelic 3D culture model to study the development of brain cellular systems. Pharmacol Res Perspect 6 24953 PMID: 27112667

Do you know of a great paper that uses Ivermectin from Tocris? If so please let us know.

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