IT1t dihydrochloride

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Description: Potent CXCR4 antagonist
Chemical Name: N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (7)
Reviews
Literature (1)

Biological Activity for IT1t dihydrochloride

IT1t dihydrochloride is a potent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).

Technical Data for IT1t dihydrochloride

M. Wt 479.57
Formula C21H34N4S2.2HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1092776-63-0
PubChem ID 25178351
InChI Key HFXJOXOIINQOEB-UHFFFAOYSA-N
Smiles CC1(C)CN(C(CS/C(NC4CCCCC4)=N/C3CCCCC3)=CS2)C2=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IT1t dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.8 10
water 47.96 100

Preparing Stock Solutions for IT1t dihydrochloride

The following data is based on the product molecular weight 479.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.43 mL 20.85 mL
5 mM 0.42 mL 2.09 mL 4.17 mL
10 mM 0.21 mL 1.04 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets for IT1t dihydrochloride

References for IT1t dihydrochloride

References are publications that support the biological activity of the product.

Thoma et al (2008) Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J.Med.Chem. 51 7915 PMID: 19053768


If you know of a relevant reference for IT1t dihydrochloride, please let us know.

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View all Chemokine CXC Receptor Antagonists

Keywords: IT1t dihydrochloride, IT1t dihydrochloride supplier, CXCR4, antagonists, HIV, envelope, protein, gp120, chemokines, receptors, type, 4, Chemokine, CXC, Receptors, 4596, Tocris Bioscience

7 Citations for IT1t dihydrochloride

Citations are publications that use Tocris products. Selected citations for IT1t dihydrochloride include:

Mathias et al (2021) Cell surface thermal proteome profiling tracks perturbations and drug targets on the plasma membrane. Nat Methods 18 84-91 PMID: 33398190

Yung-Chi et al (2019) Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant. Cell Chem Biol 26 662-673.e7 PMID: 30827936

Martin J et al (2020) Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4. Mol Pharmacol 98 72-87 PMID: 32474443

Ludger et al (2020) Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands. Sci Rep 10 16036 PMID: 32994431


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.