IT1t dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4596 - IT1t dihydrochloride | C21H34N4S2.2HCl | CAS No. 1092776-63-0
Description: Potent CXCR4 antagonist
Chemical Name: N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).

Compound Libraries

IT1t dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 479.57
Formula C21H34N4S2.2HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1092776-63-0
PubChem ID 25178351
InChI Key HFXJOXOIINQOEB-UHFFFAOYSA-N
Smiles CC1(C)CN(C(CS/C(NC4CCCCC4)=N/C3CCCCC3)=CS2)C2=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.8 10
ethanol 23.98 50
water 47.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 479.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.43 mL 20.85 mL
5 mM 0.42 mL 2.09 mL 4.17 mL
10 mM 0.21 mL 1.04 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Thoma et al (2008) Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J.Med.Chem. 51 7915 PMID: 19053768


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Keywords: CXCR4 antagonists HIV envelope protein gp120 chemokines receptors type 4 Chemokine CXC Receptors

Citations for IT1t dihydrochloride

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Literature in this Area

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Pathways for IT1t dihydrochloride

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