iso-PPADS tetrasodium salt

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Cat.No. 0683 - iso-PPADS tetrasodium salt | C14H10N3Na4O12PS2 | CAS No. 207572-67-6
Description: P2X antagonist
Chemical Name: Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt
Datasheet
Citations (1)
Literature

Biological Activity

P2X-purinoceptor antagonist (pKi = 6.5) with similar activity to PPADS (Cat. No. 0625).

Technical Data

M. Wt 599.3
Formula C14H10N3Na4O12PS2
Storage Desiccate at -20°C
CAS Number 207572-67-6
PubChem ID 5132514
InChI Key LOTSPVPQHAUHCE-UHFFFAOYSA-N
Smiles [Na+].[Na+].CC1=C(O)C(C=O)=C(CCP([O-])([O-])=O)C(\N=N\C2=C(C=CC(=C2)S(O)(=O)=O)S(O)(=O)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 59.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 599.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.67 mL 8.34 mL 16.69 mL
5 mM 0.33 mL 1.67 mL 3.34 mL
10 mM 0.17 mL 0.83 mL 1.67 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Connolly (1995) Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia. Br.J.Pharmacol. 114 727 PMID: 7735699

Khakh et al (1994) Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. Eur.J.Pharmacol. 263 301 PMID: 7843268

Trezise et al (1994) The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate. Br.J.Pharmacol. 112 282 PMID: 8032652


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Keywords: iso-PPADS tetrasodium salt, supplier, P2X, antagonists, Receptors, Purinergic, purinoceptors, P2X, Receptors, P2X, Receptors, Tocris Bioscience

1 Citation for iso-PPADS tetrasodium salt

Citations are publications that use Tocris products. Selected citations for iso-PPADS tetrasodium salt include:

Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Am J Physiol Renal Physiol 14 201 PMID: 26597723


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