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iso-PPADS tetrasodium salt
P2X-purinoceptor antagonist (pKi = 6.5) with similar activity to PPADS.
2'4'-isomer also available.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 599.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.67 mL||8.34 mL||16.69 mL|
|5 mM||0.33 mL||1.67 mL||3.34 mL|
|10 mM||0.17 mL||0.83 mL||1.67 mL|
|50 mM||0.03 mL||0.17 mL||0.33 mL|
References are publications that support the biological activity of the product.
Connolly (1995) Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia. Br.J.Pharmacol. 114 727 PMID: 7735699
Khakh et al (1994) Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. Eur.J.Pharmacol. 263 301 PMID: 7843268
Trezise et al (1994) The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate. Br.J.Pharmacol. 112 282 PMID: 8032652
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Keywords: iso-PPADS tetrasodium salt, iso-PPADS tetrasodium salt supplier, P2X, antagonists, Receptors, Purinergic, purinoceptors, 0683, Tocris Bioscience
5 Citations for iso-PPADS tetrasodium salt
Citations are publications that use Tocris products. Selected citations for iso-PPADS tetrasodium salt include:
Uderhardt et al (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177 541 PMID: 30955887
Palygin et al (2018) Characterization of purinergic receptor expression in ARPKD cystic epithelia. Purinergic Signal 14 485 PMID: 30417216
Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Am J Physiol Renal Physiol 14 201 PMID: 26597723
Accorsi-Mendonça et al (2013) Glial cells modulate the synaptic transmission of NTS neurons sending projections to ventral medulla of Wistar rats. Physiol Rep 1 e00080 PMID: 24303152
Barría et al (2018) Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes. Am J Trop Med Hyg 98 105 PMID: 29141748
Do you know of a great paper that uses iso-PPADS tetrasodium salt from Tocris? Please let us know.
Reviews for iso-PPADS tetrasodium salt
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.