iso-PPADS tetrasodium salt
P2X-purinoceptor antagonist (pKi = 6.5) with similar activity to PPADS (Cat. No. 0625).
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 599.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.67 mL||8.34 mL||16.69 mL|
|5 mM||0.33 mL||1.67 mL||3.34 mL|
|10 mM||0.17 mL||0.83 mL||1.67 mL|
|50 mM||0.03 mL||0.17 mL||0.33 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Connolly (1995) Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia. Br.J.Pharmacol. 114 727 PMID: 7735699
Khakh et al (1994) Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. Eur.J.Pharmacol. 263 301 PMID: 7843268
Trezise et al (1994) The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate. Br.J.Pharmacol. 112 282 PMID: 8032652
If you know of a relevant reference for iso-PPADS tetrasodium salt, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: iso-PPADS tetrasodium salt, supplier, P2X, antagonists, Receptors, Purinergic, purinoceptors, P2X, Receptors, Tocris Bioscience
1 Citation for iso-PPADS tetrasodium salt
Citations are publications that use Tocris products. Selected citations for iso-PPADS tetrasodium salt include:
Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Am J Physiol Renal Physiol 14 201 PMID: 26597723
Do you know of a great paper that uses iso-PPADS tetrasodium salt from Tocris? If so please let us know.
Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.