iso-PPADS tetrasodium salt

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Cat.No. 0683 - iso-PPADS tetrasodium salt | C14H10N3Na4O12PS2 | CAS No. 207572-67-6
Description: P2X antagonist
Chemical Name: Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt
Datasheet
Citations (5)
Reviews (1)
Literature (5)

Biological Activity

P2X-purinoceptor antagonist (pKi = 6.5) with similar activity to PPADS.

2'4'-isomer also available.

Technical Data

M. Wt 599.3
Formula C14H10N3Na4O12PS2
Storage Desiccate at -20°C
CAS Number 207572-67-6
PubChem ID 5132514
InChI Key LOTSPVPQHAUHCE-UHFFFAOYSA-N
Smiles [Na+].[Na+].CC1=C(O)C(C=O)=C(CCP([O-])([O-])=O)C(\N=N\C2=C(C=CC(=C2)S(O)(=O)=O)S(O)(=O)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 59.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 599.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.67 mL 8.34 mL 16.69 mL
5 mM 0.33 mL 1.67 mL 3.34 mL
10 mM 0.17 mL 0.83 mL 1.67 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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References

References are publications that support the biological activity of the product.

Connolly (1995) Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia. Br.J.Pharmacol. 114 727 PMID: 7735699

Khakh et al (1994) Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. Eur.J.Pharmacol. 263 301 PMID: 7843268

Trezise et al (1994) The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate. Br.J.Pharmacol. 112 282 PMID: 8032652


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Keywords: iso-PPADS tetrasodium salt, iso-PPADS tetrasodium salt supplier, P2X, antagonists, Receptors, Purinergic, purinoceptors, 0683, Tocris Bioscience

5 Citations for iso-PPADS tetrasodium salt

Citations are publications that use Tocris products. Selected citations for iso-PPADS tetrasodium salt include:

Uderhardt et al (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177 541 PMID: 30955887

Palygin et al (2018) Characterization of purinergic receptor expression in ARPKD cystic epithelia. Purinergic Signal 14 485 PMID: 30417216

Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Am J Physiol Renal Physiol 14 201 PMID: 26597723

Accorsi-Mendonça et al (2013) Glial cells modulate the synaptic transmission of NTS neurons sending projections to ventral medulla of Wistar rats. Physiol Rep 1 e00080 PMID: 24303152

Barría et al (2018) Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes. Am J Trop Med Hyg 98 105 PMID: 29141748


Do you know of a great paper that uses iso-PPADS tetrasodium salt from Tocris? Please let us know.

Reviews for iso-PPADS tetrasodium salt

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Good inhibitor.
By Anonymous on 06/06/2020
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: phagocyte

H20 dilution 100 μM

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