Isamoltane hemifumarate

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Cat.No. 0992 - Isamoltane hemifumarate | C16H22N2O2.½C4H4O4 | CAS No. 874882-92-5
Description: 5-HT1B antagonist
Chemical Name: 1-[(1-Methylethyl)amino]-3-[2-(1H-pyrrol-1-yl)]-propan-2-ol hemifumarate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

5-HT1B antagonist, approximately 30-fold selective over 5-HT1A. Also possesses affinity for β-adrenergic receptors.

Technical Data

M. Wt 332.4
Formula C16H22N2O2.½C4H4O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 874882-92-5
PubChem ID 45073435
InChI Key MCHSBYUSDSJLAQ-WXXKFALUSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].CC(C)NCC(O)COC1=CC=CC=C1N1C=CC=C1.CC(C)NCC(O)COC1=CC=CC=C1N1C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 3.32 10mM with gentle warming
water 3.32 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 332.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.08 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Waldmeier et al (1988) Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain. Naunyn Schmiedebergs Arch.Pharmacol. 337 609 PMID: 2905765


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Keywords: Isamoltane hemifumarate, supplier, 5-HT1B, antagonist, Serotonin, Receptors, 5-HT1B, Receptors, 5-HT1B, Receptors, Tocris Bioscience

Citations for Isamoltane hemifumarate

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