IRL-2500

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Cat.No. 1838 - IRL-2500 | C36H35N3O4 | CAS No. 169545-27-1
Description: Potent ETB antagonist
Chemical Name: N-3-[1,1'-Biphenyl]-4-yl-N-(3,5-dimethylbenzoyl)-N-methyl-D-alanyl-L-tryptophan
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent endothelin receptor antagonist; shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.

Technical Data

M. Wt 573.69
Formula C36H35N3O4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 169545-27-1
PubChem ID 5311192
InChI Key UZDORQWMYRRLQV-JHOUSYSJSA-N
Smiles O=C([C@@H](CC4=CC=C(C5=CC=CC=C5)C=C4)N(C)C(C3=CC(C)=CC(C)=C3)=O)N[C@H]([C@@](O)=O)CC1=CNC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 43.03 75mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 573.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.74 mL 8.72 mL 17.43 mL
5 mM 0.35 mL 1.74 mL 3.49 mL
10 mM 0.17 mL 0.87 mL 1.74 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Balwierczak et al (1995) Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500. J.Cardiovasc.Pharmacol. 26 S393 PMID: 8587424

Leung et al (2002) Use of A-192621 and IRL-2500 to unmask the mesenteric and renal vasodilator role of endothelin ETB receptors. J.Cardiovasc.Pharmacol. 39 533 PMID: 11904527

Webb et al (1995) Effects of the ETB-selective antagonist IRL 2500 in conscious spontaneously hypertensive and Wistar-Kyoto rats. J.Cardiovasc.Pharmacol. 26 S389 PMID: 8587423


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Keywords: IRL-2500, supplier, Potent, ETB, antagonists, Receptors, Endothelin, IRL2500, Endothelin, ETB, Receptors, Tocris Bioscience

Citations for IRL-2500

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Pathways for IRL-2500

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