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Ipsapirone is a selective 5-HT1A receptor agonist (Ki = 10 nM). Anxiolytic in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 401.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||24.91 mL||124.54 mL||249.08 mL|
|0.5 mM||4.98 mL||24.91 mL||49.82 mL|
|1 mM||2.49 mL||12.45 mL||24.91 mL|
|5 mM||0.5 mL||2.49 mL||4.98 mL|
References are publications that support the biological activity of the product.
Maj et al (1987) Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and DArgic functions. J.Neural.Transm. 70 1 PMID: 2889795
Glaser and Traber (1985) Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sites. Naunyn-Schmied.Arch.Pharmacol. 329 211
Traber et al (1984) Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821. Brain Res.Bull. 12 741 PMID: 6541079
If you know of a relevant reference for Ipsapirone, please let us know.
Keywords: Ipsapirone, Ipsapirone supplier, Selective, 5-HT1A, agonists, Serotonin, Receptors, TVXQ7821, TVX, Q, 7821, 1869, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Ipsapirone include:
Borroto-Escuela et al (2017) Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition. ACS Omega 2 4779 PMID: 28920103
Rozeske et al (2011) Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus. J Neurosci 31 14107 PMID: 21976495
Do you know of a great paper that uses Ipsapirone from Tocris? Please let us know.
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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