Ipsapirone

Pricing Availability Delivery Time Qty
Cat.No. 1869 - Ipsapirone | C19H23N5O3S | CAS No. 95847-70-4
Description: Selective 5-HT1A agonist
Alternative Names: TVX Q 7821
Chemical Name: 2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one-1,1-dioxide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective 5-HT1A receptor agonist (Ki = 10 nM). Anxiolytic in vivo.

Technical Data

M. Wt 401.48
Formula C19H23N5O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 95847-70-4
PubChem ID 56971
InChI Key TZJUVVIWVWFLCD-UHFFFAOYSA-N
Smiles O=C1N(CCCCN2CCN(CC2)C2=NC=CC=N2)S(=O)(=O)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.01 10

Preparing Stock Solutions

The following data is based on the product molecular weight 401.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.45 mL 24.91 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.25 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Maj et al (1987) Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions. J.Neural.Transm. 70 1 PMID: 2889795

Glaser and Traber (1985) Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sites. Naunyn-Schmied.Arch.Pharmacol. 329 211 PMID:

Traber et al (1984) Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821. Brain Res.Bull. 12 741 PMID: 6541079


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Keywords: Selective 5-HT1A agonists Serotonin Receptors TVXQ7821 TVX Q 7821 5-HT1A Receptors

1 Citation for Ipsapirone

Citations are publications that use Tocris products. Selected citations for Ipsapirone include:

Rozeske et al (2011) Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus. J Neurosci 31 14107 PMID: 21976495


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Reviews

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Pathways for Ipsapirone

Protocols

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