Iodophenpropit dihydrobromide

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Cat.No. 0779 - Iodophenpropit dihydrobromide | C15H19IN4S.2HBr | CAS No. 145196-87-8
Description: Potent, selective H3 antagonist
Chemical Name: N-[2-(4-Iodophenyl)ethyl]-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective H3 antagonist with high affinity (KD = 0.3 nM). Also available as part of the Histamine H3 Receptor Tocriset™.

Licensing Information

Sold with the permission of SCI, Amsterdam

Technical Data

M. Wt 576.13
Formula C15H19IN4S.2HBr
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 145196-87-8
PubChem ID 24978528
InChI Key BOSOGNBLIWPCMS-UHFFFAOYSA-N
Smiles Br.Br.IC1=CC=C(CCNC(=N)SCCCC2=CNC=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 5.76 10
water 14.4 25

Preparing Stock Solutions

The following data is based on the product molecular weight 576.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.74 mL 8.68 mL 17.36 mL
5 mM 0.35 mL 1.74 mL 3.47 mL
10 mM 0.17 mL 0.87 mL 1.74 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Jansen et al (1992) The first radiolabelled histamine H3 receptor antagonist, [125I]iodophenpropit: saturable and reversible binding to rat cortex membranes. Eur.J.Pharmacol. 217 203 PMID: 1330590

Jansen et al (1994) Characterisation of the binding of the first selective radiolabelled histamine H3 receptor antagonist, [125I]-iodophenpropit, to rat brain. Br.J.Pharmacol. 113 355 PMID: 7834183

Menge et al (1992) Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites. J.Labelled Comp.Radiopharm. XXXI 10 781 PMID:

Shahid et al (2009) Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9 PMID:


If you know of a relevant reference for Iodophenpropit dihydrobromide, please let us know.

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Keywords: Potent selective H3 antagonists Receptors Histamine histaminergic Histamine H3 Receptors

2 Citations for Iodophenpropit dihydrobromide

Citations are publications that use Tocris products. Selected citations for Iodophenpropit dihydrobromide include:

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. BMC Neurosci 7 2336 PMID: 26114334

Spaethling et al (2014) Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. Toxins (Basel) 28 771 PMID: 24192459


Do you know of a great paper that uses Iodophenpropit dihydrobromide from Tocris? If so please let us know.

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