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Indinavir sulfate New
Biological Activity for Indinavir sulfate
Indinavir sulfate is a potent and selective HIV protease inhibitor (Ki values are 0.52 and 3.3 nM for HIV-1 and HIV-2, respectively). Indinavir stops the spread of the HIV-infected MT4 lymphoid cells at concentrations of 25-50 nM. Indinavir disrupts the ERK1/2 and p38 MAPK pathways and reduces both the level of functional eIF4F complex and rpS6 phosphorylation, which leads to a decrease in protein synthesis in mouse myocytes. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CLpro.
Technical Data for Indinavir sulfate
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Indinavir sulfate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Indinavir sulfate
The following data is based on the product molecular weight 711.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.4 mL||7.02 mL||14.05 mL|
|5 mM||0.28 mL||1.4 mL||2.81 mL|
|10 mM||0.14 mL||0.7 mL||1.4 mL|
|50 mM||0.03 mL||0.14 mL||0.28 mL|
Product Datasheets for Indinavir sulfate
References for Indinavir sulfate
References are publications that support the biological activity of the product.
Dorsey et al (1994) L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor. J.Med.Chem. 37 3443 PMID: 7932573
Brown et al (2004) Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C2C12 myocytes. Am.J.Physiol.Cell Physiol. 287 C1482-92 PMID: 15229102
Brown et al (2005) Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Am.J.Physiol.Endocrinol.Metab. 289 E382-90 PMID: 15827064
Hall et al (2020) A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease. Travel Med.Infect.Dis. 35 101646 PMID: 32294562
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Citations for Indinavir sulfate
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Literature in this Area
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