Indinavir sulfate

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Description: Potent and selective HIV-1 and HIV-2 protease inhibitor
Chemical Name: 2,3,5-Trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for Indinavir sulfate

Indinavir sulfate is a potent and selective HIV protease inhibitor (Ki values are 0.52 and 3.3 nM for HIV-1 and HIV-2, respectively). Indinavir stops the spread of the HIV-infected MT4 lymphoid cells at concentrations of 25-50 nM. Indinavir disrupts the ERK1/2 and p38 MAPK pathways and reduces both the level of functional eIF4F complex and rpS6 phosphorylation, which leads to a decrease in protein synthesis in mouse myocytes. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CLpro.

Technical Data for Indinavir sulfate

M. Wt 711.88
Formula C36H47N5O4.H2SO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 157810-81-6
PubChem ID 5462355
InChI Key NUBQKPWHXMGDLP-BDEHJDMKSA-N
Smiles S(=O)(=O)(O)O.N(C([C@H](CC1=CC=CC=C1)C[C@@H](CN2[C@H](C(NC(C)(C)C)=O)CN(CC=3C=CC=NC3)CC2)O)=O)[C@H]4C=5C(C[C@H]4O)=CC=CC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Indinavir sulfate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 71.19 100
water 71.19 100

Preparing Stock Solutions for Indinavir sulfate

The following data is based on the product molecular weight 711.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.4 mL 7.02 mL 14.05 mL
5 mM 0.28 mL 1.4 mL 2.81 mL
10 mM 0.14 mL 0.7 mL 1.4 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets for Indinavir sulfate

References for Indinavir sulfate

References are publications that support the biological activity of the product.

Dorsey et al (1994) L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor. J.Med.Chem. 37 3443 PMID: 7932573

Brown et al (2004) Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C2C12 myocytes. Am.J.Physiol.Cell Physiol. 287 C1482-92 PMID: 15229102

Brown et al (2005) Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Am.J.Physiol.Endocrinol.Metab. 289 E382-90 PMID: 15827064

Hall et al (2020) A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease. Travel Med.Infect.Dis. 35 101646 PMID: 32294562


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Citations for Indinavir sulfate

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Literature in this Area

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Immunology Product Listing

Immunology Product Listing

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  • Complement System
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