Indibulin

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Cat.No. 3728 - Indibulin | C22H16ClN3O2 | CAS No. 204205-90-3
Description: Microtubule destabilizer
Alternative Names: D 24851
Chemical Name: 2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Microtubule destabilizer that blocks tubulin polymerization (IC50 = 0.3 μM). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC50 values ranging from 0.036 - 0.285 μM). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo. Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.

Technical Data

M. Wt 389.83
Formula C22H16ClN3O2
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 204205-90-3
PubChem ID 2929
InChI Key SOLIIYNRSAWTSQ-UHFFFAOYSA-N
Smiles ClC(C=C3)=CC=C3CN2C1=CC=CC=C1C(C(C(NC4=CC=NC=C4)=O)=O)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.75 25

Preparing Stock Solutions

The following data is based on the product molecular weight 389.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.26 mL 51.3 mL 102.61 mL
1.25 mM 2.05 mL 10.26 mL 20.52 mL
2.5 mM 1.03 mL 5.13 mL 10.26 mL
12.5 mM 0.21 mL 1.03 mL 2.05 mL

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References

References are publications that support the biological activity of the product.

Bacher et al (2001) D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity. Cancer Res. 61 392 PMID: 11196193

Kanzawa et al (2005) Microtubule inhibitor D-24851 induces p53-independent apoptotic cell death in malignant glioma cells through Bcl-2 phosphorylation and Bax translocation. Int.J.Oncol. 26 589 PMID: 15703812

Wienecke and Bacher (2009) Indibulin, a novel microtubule inhibitor, discriminates between mature and nonneuronal tubulin. Cancer Res. 69 171 PMID: 19118000


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Keywords: Indibulin, Indibulin supplier, microtubule, destabilizers, destabilisers, mitosis, tubulin, tau, D24851, D, 24851, Microtubules, Mitosis, 3728, Tocris Bioscience

Citations for Indibulin

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