IN 1130

Pricing Availability   Qty
Description: Potent and selective inhibitor of TGF-βRI
Chemical Name: 3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide
Purity: ≥98% (HPLC)
Literature (3)
Pathways (1)

Biological Activity for IN 1130

IN 1130 is a potent and selective inhibitor of TGF-β type I receptor (ALK5). Inhibits Smad-2 phosphorylation (IC50 = 5.3 nM). Exhibits selectivity over a panel of 27 serine/ threonine and tyrosine kinases including P38α. Attenuates TGFβ/Smad signaling, cell migration, invasion, lung metastasis and increases survival of mice in 4TI in vivo models. Suppresses renal fibrosis in obstructive nephropathy in vivo models.

Technical Data for IN 1130

M. Wt 420.47
Formula C25H20N6O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 868612-83-3
PubChem ID 11676119
Smiles CC1=NC(C2=C(C3=CC4=C(N=CC=N4)C=C3)NC(CC5=CC(C(N)=O)=CC=C5)=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IN 1130

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.05 100
1eq. HCl 42.05 100

Preparing Stock Solutions for IN 1130

The following data is based on the product molecular weight 420.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for IN 1130

References are publications that support the biological activity of the product.

Moon et al (2006) IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy. Kidney Int. 70 1234 PMID: 16929250

Lee et al (2008) Effect of IN-1130, a small molecule inhibitor of transforming growth factor-beta type I receptor/AVNreceptor-like kinase-5, on prostate cancer cells. J.Urol. 180 2660 PMID: 18951571

Park et al (2014) An novel inhibitor of TGF-beta type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition. Cancer Lett. 351 72 PMID: 24887560

If you know of a relevant reference for IN 1130, please let us know.

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Keywords: IN 1130, IN 1130 supplier, IN1130, potent, selective, inhibitors, inhibits, TGF-β, type, I, receptor, ALK5, Smad, breast, lung, metastasis, TGF-βRI, TGF-beta, Receptors, 6016, Tocris Bioscience

Citations for IN 1130

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Currently there are no citations for IN 1130. Do you know of a great paper that uses IN 1130 from Tocris? Please let us know.

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Literature in this Area

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Stem Cell Research Product Guide

Stem Cell Research Product Guide

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Stem Cells Scientific Review

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Pathways for IN 1130

TGF-β Signaling Pathway

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.