Impentamine dihydrobromide

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Cat.No. 1858 - Impentamine dihydrobromide | C8H15N3.2HBr | CAS No. 149629-70-9
Description: Selective H3 antagonist
Alternative Names: VUF 4702
Chemical Name: 4-(5-Aminopentyl)imidazole dihydrobromide
Datasheet
Citations
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Biological Activity

Potent and highly selective histamine H3 receptor antagonist (pA2 = 8.4); displays > 30000-fold selectivity over H1 and H2 receptors. Can act as a partial agonist in SK-N-MC cells expressing human H3 receptors. Produces antinociception, possibly via a non-H1, -H2 or -H3 receptor-mediated mechanism, following central administration in vivo.

Technical Data

M. Wt 315.05
Formula C8H15N3.2HBr
Storage Desiccate at RT
CAS Number 149629-70-9
PubChem ID 53439849
InChI Key QSDXAAWBBPWGEL-UHFFFAOYSA-N
Smiles Br.Br.NCCCCCC1=CN=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.51 100
water 31.51 100

Preparing Stock Solutions

The following data is based on the product molecular weight 315.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.87 mL 31.74 mL
5 mM 0.63 mL 3.17 mL 6.35 mL
10 mM 0.32 mL 1.59 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References

References are publications that support the products' biological activity.

Hough et al (1999) Antinociceptive activity of impentamine, a histamine congener, after CNS administration. Life Sci. 64 PL79 PMID: 10072195

Vollinga et al (1995) Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole. J.Med.Chem. 38 266 PMID: 7830269

Wieland et al (2001) Constitutive activity of histamine H3 receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H3 antagonists. J.Pharmacol.Exp.Ther. 299 908 PMID: 11714875


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