Impentamine dihydrobromide

Discontinued Product

Impentamine dihydrobromide (Cat. No. 1858) has been withdrawn from sale for commercial reasons.
Description: Selective H3 antagonist
Alternative Names: VUF 4702
Chemical Name: 4-(5-Aminopentyl)imidazole dihydrobromide
Literature (2)

Biological Activity for Impentamine dihydrobromide

Impentamine dihydrobromide is a potent and highly selective histamine H3 receptor antagonist (pA2 = 8.4); displays > 30000-fold selectivity over H1 and H2 receptors. Can act as a partial agonist in SK-N-MC cells expressing human H3 receptors. Produces antinociception, possibly via a non-H1, -H2 or -H3 receptor-mediated mechanism, following central administration in vivo.

Technical Data for Impentamine dihydrobromide

M. Wt 315.05
Formula C8H15N3.2HBr
Storage Desiccate at RT
CAS Number 149629-70-9
PubChem ID 53439849
Smiles Br.Br.NCCCCCC1=CN=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Impentamine dihydrobromide

References for Impentamine dihydrobromide

References are publications that support the biological activity of the product.

Hough et al (1999) Antinociceptive activity of impentamine, a histamine congener, after CNS administration. Life Sci. 64 PL79 PMID: 10072195

Vollinga et al (1995) Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole. J.Med.Chem. 38 266 PMID: 7830269

Wieland et al (2001) Constitutive activity of histamine H3 receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H3 antagonists. J.Pharmacol.Exp.Ther. 299 908 PMID: 11714875

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Keywords: Impentamine dihydrobromide, Impentamine dihydrobromide supplier, Selective, H3, antagonists, Receptors, Histamine, histaminergic, VUF4702, VUF, 4702, 1858, Tocris Bioscience

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Literature in this Area

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Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.

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Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.