iMAC2

Pricing Availability Delivery Time Qty
Cat.No. 3794 - iMAC2 | C19H20Br2FN3.2HCl | CAS No. 335166-00-2
Description: Suppressor of mitochondrial apoptosis
Chemical Name: 3,6-Dibromo-9-[2-fluoro-3-(1-piperazinyl)propyl]-9H-carbazole dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM).

Technical Data

M. Wt 542.11
Formula C19H20Br2FN3.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 335166-00-2
PubChem ID 90488878
InChI Key JWCVUOLQOHIRML-UHFFFAOYSA-N
Smiles BrC(C=C3)=CC1=C3N(CC(F)CN4CCNCC4)C2=C1C=C(Br)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.71 5

Preparing Stock Solutions

The following data is based on the product molecular weight 542.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.22 mL 18.45 mL
5 mM 0.37 mL 1.84 mL 3.69 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bombrun et al (2003) 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 4365 PMID: 14521400

Peixoto et al (2009) MAC inhibitors suppress mitochondrial apoptosis. Biochem.J. 423 381 PMID: 19691447


If you know of a relevant reference for iMAC2, please let us know.

View Related Products by Target

Keywords: iMAC2, supplier, MAC, inhibitor, mitochondrial, apoptosis-induced, channel, inhibitors, inhibits, reduces, apoptosis, bax, Other, Apoptosis, Tocris Bioscience

Citations for iMAC2

Citations are publications that use Tocris products.

Currently there are no citations for iMAC2. Do you know of a great paper that uses iMAC2 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for iMAC2

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Protocols

TODO: Add Protocols