You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 542.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||36.89 mL||184.46 mL||368.93 mL|
|0.25 mM||7.38 mL||36.89 mL||73.79 mL|
|0.5 mM||3.69 mL||18.45 mL||36.89 mL|
|2.5 mM||0.74 mL||3.69 mL||7.38 mL|
References are publications that support the biological activity of the product.
Bombrun et al (2003) 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 4365 PMID: 14521400
Peixoto et al (2009) MAC inhibitors suppress mitochondrial apoptosis. Biochem.J. 423 381 PMID: 19691447
If you know of a relevant reference for iMAC2, please let us know.
Keywords: iMAC2, iMAC2 supplier, MAC, inhibitor, mitochondrial, apoptosis-induced, channel, inhibitors, inhibits, reduces, apoptosis, bax, Other, Apoptosis, Bcl-2, Family, 3794, Tocris Bioscience
Citations for iMAC2
Citations are publications that use Tocris products.
Currently there are no citations for iMAC2. Do you know of a great paper that uses iMAC2 from Tocris? Please let us know.
Reviews for iMAC2
There are currently no reviews for this product. Be the first to review iMAC2 and earn rewards!
Have you used iMAC2?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.