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Cat.No. 3794 - iMAC2 | C19H20Br2FN3.2HCl | CAS No. 335166-00-2
Description: Suppressor of mitochondrial apoptosis
Chemical Name: 3,6-Dibromo-9-[2-fluoro-3-(1-piperazinyl)propyl]-9H-carbazole dihydrochloride
Purity: ≥98% (HPLC)
Literature (2)
Pathways (1)

Biological Activity

Inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM).

Technical Data

M. Wt 542.11
Formula C19H20Br2FN3.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 335166-00-2
PubChem ID 90488878
Smiles BrC(C=C3)=CC1=C3N(CC(F)CN4CCNCC4)C2=C1C=C(Br)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 2.71 5

Preparing Stock Solutions

The following data is based on the product molecular weight 542.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 36.89 mL 184.46 mL 368.93 mL
0.25 mM 7.38 mL 36.89 mL 73.79 mL
0.5 mM 3.69 mL 18.45 mL 36.89 mL
2.5 mM 0.74 mL 3.69 mL 7.38 mL

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References are publications that support the biological activity of the product.

Bombrun et al (2003) 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 4365 PMID: 14521400

Peixoto et al (2009) MAC inhibitors suppress mitochondrial apoptosis. Biochem.J. 423 381 PMID: 19691447

If you know of a relevant reference for iMAC2, please let us know.

View Related Products by Target

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Citations for iMAC2

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Literature in this Area

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for iMAC2


Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.