IEM 1754 dihydrobromide

Pricing Availability Delivery Time Qty
Cat.No. 4199 - IEM 1754 dihydrobromide | C16H30N2.2HBr | CAS No. 162831-31-4
Description: Voltage-dependent, open-channel blocker of AMPA currents
Chemical Name: N-(Tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1,5-pentanediamine dihydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Voltage-dependent open-channel blocker of AMPA receptors. Selective between subtypes; blocks GluR2 subunit-lacking (Ca2+-permeable) receptors more potently than GluR2-containing receptors. Also potently blocks NMDA receptor channels. Less sensitive than IEM 1460 (Cat. No. 1460) at a holding potential between -40 and -80mV.

Technical Data

M. Wt 412.25
Formula C16H30N2.2HBr
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 162831-31-4
PubChem ID 9887867
InChI Key JMPHTNNJCZDROM-UHFFFAOYSA-N
Smiles NCCCCCNCC1(CC3C2)CC(C3)CC2C1.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water and to 50 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 412.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.13 mL 24.26 mL
5 mM 0.49 mL 2.43 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Magazanik et al (1997) Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J.Physiol. 505 655 PMID: 9457643

Tikhonov et al (2000) Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 129 265 PMID: 10694232


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Keywords: IEM1754 2HBr AMPA receptor blocker blocks AMPAR voltage-dependent AMPA Receptors

Citations for IEM 1754 dihydrobromide

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