IEM 1754 dihydrobromide
Voltage-dependent open-channel blocker of AMPA receptors. Selective between subtypes; blocks GluR2 subunit-lacking (Ca2+-permeable) receptors more potently than GluR2-containing receptors. Also potently blocks NMDA receptor channels. Less sensitive than IEM 1460 (Cat. No. 1460) at a holding potential between -40 and -80mV.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water and to 50 mM in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 412.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.43 mL||12.13 mL||24.26 mL|
|5 mM||0.49 mL||2.43 mL||4.85 mL|
|10 mM||0.24 mL||1.21 mL||2.43 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Magazanik et al (1997) Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J.Physiol. 505 655 PMID: 9457643
Tikhonov et al (2000) Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 129 265 PMID: 10694232
If you know of a relevant reference for IEM 1754 dihydrobromide, please let us know.
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Keywords: IEM1754 2HBr AMPA receptor blocker blocks AMPAR voltage-dependent AMPA Receptors
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