IDRA 21

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Cat.No. 1219 - IDRA 21 | C8H9ClN2O2S | CAS No. 22503-72-6
Description: Inhibits AMPA receptor desensitization
Chemical Name: 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (Cat. No. 0713).

Compound Libraries

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Technical Data

M. Wt 232.68
Formula C8H9ClN2O2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 22503-72-6
PubChem ID 3688
InChI Key VZRNTCHTJRLTMU-UHFFFAOYSA-N
Smiles CC1NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 232.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.3 mL 21.49 mL 42.98 mL
5 mM 0.86 mL 4.3 mL 8.6 mL
10 mM 0.43 mL 2.15 mL 4.3 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Impagnatiello et al (1997) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity. Proc.Natl.Acad.Sci.U.S.A. 94 7053 PMID: 9192690

Thompson et al (1995) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys. Proc.Natl.Acad.Sci.U.S.A. 92 7667 PMID: 7644474

Zivkovic et al (1995) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-α-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization. J.Pharmacol.Exp.Ther. 272 300 PMID: 7815345


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Keywords: IDRA 21, supplier, inhibitors, inhibits, AMPA, receptor, desensitization, desensitisation, Glutamate, Receptors, iGlur, Ionotropic, IDRA21, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience

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