ICI 154,129

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Cat.No. 0827 - ICI 154,129 | N,N-diallyl-Tyr-Gly-ψ-(CH2S)-Phe-Leu-OH | CAS No. 83420-94-4
Description: δ selective peptide antagonist
Datasheet
Citations (1)
Literature

Biological Activity

Selective δ opioid antagonist.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 638.83
Formula C34H46N4O6S
Sequence YGFL

(Modifications: Tyr-1 = N,N-diallyl-Tyr, Gly-2 - Phe-3 peptide bond replaced with Psi-(CH2S))

Storage Desiccate at -20°C
CAS Number 83420-94-4
PubChem ID 3035055
InChI Key CZRZYRKTYLLLRL-DTXPUJKBSA-N
Smiles CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)SCCNC(=O)CNC(=O)[C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in methanol

Preparing Stock Solutions

The following data is based on the product molecular weight 638.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.57 mL 7.83 mL 15.65 mL
5 mM 0.31 mL 1.57 mL 3.13 mL
10 mM 0.16 mL 0.78 mL 1.57 mL
50 mM 0.03 mL 0.16 mL 0.31 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Shaw et al (1982) Selective antagonists at the opiate delta-receptor. Life Sci. 31 1259 PMID: 6128652

Rees and Hunter (1990) Opioid Receptors. Comprehensive Medicinal Chemistry. Ed. Hansch. 3 805 PMID:


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Keywords: ICI 154,129, supplier, δ-opioid, delta-opioid, selective, peptide, antagonists, DOP, Receptors, OP1, ICI154129, AstraZeneca, Delta, Opioid, Receptors, Tocris Bioscience

1 Citation for ICI 154,129

Citations are publications that use Tocris products. Selected citations for ICI 154,129 include:

Jiang et al (2015) Analgesic roles of peripheral intrinsic met-enkephalin and dynorphin A in long-lasting inflammatory pain induced by complete Freund's adjuvant in rats. J Pharmacol Exp Ther 9 2344 PMID: 26136984


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