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Description: Near-infrared (NIR) fluorescent dye; partially deuterated form of Indocyanine Green (Cat. No. 7510), suitable for in vivo imaging.
Chemical Name: Sodium 4-(2-((1E,3E,5E,7Z)-7-(1,1-Dimethyl-3-(4-sulfonatobutyl)-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl-1,2,3,4,5,6,7-d7)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonate
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for ICG-d7

Key information: ICG-d7 is a partially deuterated form of near-infrared fluorescent dye Indocyanine Green (ICG; Cat. No. 7510).

Application: Fluorescence microscopy, in vivo imaging.

Properties and Photophysical Data: ICG-d7 operates in the 700 - 900 nm wavelength range; also exhibits fluorescence emission in the shortwave infrared window (SWIR; 1,000 - 2,000 nm) which enables in vivo imaging. ICG-d7 shows improved stability in aqueous solutions over ICG with the same fluorescence brightness, and similar absorption and emission maxima in both DMSO and FBS. Excitation and emission maxima (λ) are 794 nm and 818 nm, respectively; quantum yield = 0.21; extinction coefficient = 228,000 M-1cm-1.

Licensing Information

Sold under license from the University of Notre Dame

Optical Data for ICG-d7

ICG-d7 Dye Spectra
Emission Color Near-IR
λabs 794 nm
λem 818 nm
Extinction Coefficient (ε) 228000 M-1cm-1
Quantum Yield (φ) 0.21
Application Fluorescence Microscopy, In Vivo Imaging
Alternative For Indocyanine green

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Technical Data for ICG-d7

M. Wt 782.01
Formula C43H40D7N2O6S2Na
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2861905-57-7
Smiles CC1(C)/C(N(CCCCS(=O)(O[Na])=O)C2=C1C3=CC=CC=C3C=C2)=C(/C([2H])=C(/C([2H])=C(/C([2H])=C(C4=[N+](CCCCS([O-])(=O)=O)C5=C(C6=CC=CC=C6C=C5)C4(C)C)\[2H])[2H])[2H])[2H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ICG-d7

Solvent Max Conc. mg/mL Max Conc. mM
water 7.82 10
DMSO 7.82 10

Preparing Stock Solutions for ICG-d7

The following data is based on the product molecular weight 782.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.79 mL 63.94 mL 127.88 mL
0.5 mM 2.56 mL 12.79 mL 25.58 mL
1 mM 1.28 mL 6.39 mL 12.79 mL
5 mM 0.26 mL 1.28 mL 2.56 mL

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References for ICG-d7

References are publications that support the biological activity of the product.

Li and Smith (2021) Deuterated indocyanine green (ICG) with extended aqueous storage shelf-life: chemical and clinical implications. Chemistry 27 14535 PMID: 34403531

If you know of a relevant reference for ICG-d7, please let us know.

Keywords: ICG-d7, ICG-d7 supplier, ICGd7, indocyanine, cyanine, green, deuterated, deuterium, NIR, near, infrared, fluorescent, fluorescence, stable, stability, short, wave, infra, red, labeling, Near, Infrared, (NIR), Fluorescent, Dyes, Cyanine, (Cy, Dyes), Stable, Isotopically, Labeled, Compounds, 7749, Tocris Bioscience

Citations for ICG-d7

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