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I 432 is a TMPRSS2 (transmembrane serine proteinase 2) inhibitor (Ki =0.9 nM). It blocks influenza virus propagation in airway epithelial cells. In IPEC-J2 pig jejunal epithelial cells, I 432 (50 μM) inhibits TMPRSS2 without affecting cell viability after 48 h treatment.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 830.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.2 mL||6.02 mL||12.04 mL|
|5 mM||0.24 mL||1.2 mL||2.41 mL|
|10 mM||0.12 mL||0.6 mL||1.2 mL|
|50 mM||0.02 mL||0.12 mL||0.24 mL|
References are publications that support the biological activity of the product.
Meyer et al (2013) Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation. Biochem J. 452 331 PMID: 23527573
Pászti-Gere et al (2016) In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells. J.Enzyme Inhib.Med.Chem. 31 123 PMID: 27277342
Alexander et al (2020) A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development: IUPHAR Review 29. Br.J.Pharmacol. 177 4942 PMID: 32358833
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Keywords: I 432, I 432 supplier, I432, inhibitors, inhibits, TMPRSS2, transmembrane, serine, proteinase, 2, influenza, viruses, Influenza, Viruses, 7292, Tocris Bioscience
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