Discontinued Product

HI TOPK 032 (Cat. No. 4555) has been withdrawn from sale for commercial reasons.
Description: Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor
Chemical Name: N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for HI TOPK 032

HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM).

Technical Data for HI TOPK 032

M. Wt 369.4
Formula C20H11N5OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 487020-03-1
PubChem ID 1936439
Smiles O=C(C5=CC=CS5)NC4=CC3=C(C#N)C2=NC1=CC=CC=C1N=C2N3C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for HI TOPK 032

References are publications that support the biological activity of the product.

Li et al (2011) Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures. J.Chem.Inf.Model. 51 2904 PMID: 21955044

Kim et al (2012) Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer Res. 72 3060 PMID: 22523035

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Keywords: HI TOPK 032, HI TOPK 032 supplier, HITOPK032, TOPK, T-LAK-cell-originated, protein, kinase, MAPKK, inhibitors, inhibits, selective, antitumor, colon, cancer, cells, antiproliferatives, Other, MAPK, 4555, Tocris Bioscience

Citations for HI TOPK 032

Citations are publications that use Tocris products.

Currently there are no citations for HI TOPK 032.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.