HI TOPK 032

Pricing Availability   Qty
Cat.No. 4555 - HI TOPK 032 | C20H11N5OS | CAS No. 487020-03-1
Description: Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor
Chemical Name: N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM).

Technical Data

M. Wt 369.4
Formula C20H11N5OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 487020-03-1
PubChem ID 1936439
InChI Key BCSBXWKRZUPFHW-UHFFFAOYSA-N
Smiles O=C(C5=CC=CS5)NC4=CC3=C(C#N)C2=NC1=CC=CC=C1N=C2N3C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.39 20

Preparing Stock Solutions

The following data is based on the product molecular weight 369.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.54 mL 67.68 mL 135.35 mL
1 mM 2.71 mL 13.54 mL 27.07 mL
2 mM 1.35 mL 6.77 mL 13.54 mL
10 mM 0.27 mL 1.35 mL 2.71 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Li et al (2011) Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures. J.Chem.Inf.Model. 51 2904 PMID: 21955044

Kim et al (2012) Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer Res. 72 3060 PMID: 22523035


If you know of a relevant reference for HI TOPK 032, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other MAPK Inhibitors

Keywords: HI TOPK 032, HI TOPK 032 supplier, HITOPK032, TOPK, T-LAK-cell-originated, protein, kinase, MAPKK, inhibitors, inhibits, selective, antitumor, colon, cancer, cells, antiproliferatives, Other, MAPK, 4555, Tocris Bioscience

Citations for HI TOPK 032

Citations are publications that use Tocris products.

Currently there are no citations for HI TOPK 032. Do you know of a great paper that uses HI TOPK 032 from Tocris? Please let us know.

Reviews for HI TOPK 032

There are currently no reviews for this product. Be the first to review HI TOPK 032 and earn rewards!

Have you used HI TOPK 032?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.