Hexamethonium bromide

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Cat.No. 4111 - Hexamethonium bromide | C12H30Br2N2 | CAS No. 55-97-0
Description: Nicotinic receptor blocker
Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.

Technical Data

M. Wt 362.19
Formula C12H30Br2N2
Storage Desiccate at RT
CAS Number 55-97-0
PubChem ID 5938
InChI Key FAPSXSAPXXJTOU-UHFFFAOYSA-L
Smiles C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 36.22 100
DMSO 18.11 50

Preparing Stock Solutions

The following data is based on the product molecular weight 362.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.61 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Karavaev et al (2008) The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro. Neurosci.Behav.Physiol. 38 297 PMID: 18264777

Dasgupta et al (2010) Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc.Natl.Acad.Sci. 103 6332


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Citations for Hexamethonium bromide

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Reviews for Hexamethonium bromide

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Nicotinic blocker for decreasing stimulated dopamine release
By Anonymous on 05/15/2018
Assay Type: Ex Vivo
Species: Mouse

This is a fantastic drug for examining nicotinic receptor effects. It is easy to work with for slice recordings and washes out nicely. We typically use 50-200uM concentrations.

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Literature in this Area

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