Nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 362.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.76 mL||13.8 mL||27.61 mL|
|5 mM||0.55 mL||2.76 mL||5.52 mL|
|10 mM||0.28 mL||1.38 mL||2.76 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
References are publications that support the biological activity of the product.
Karavaev et al (2008) The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro. Neurosci.Behav.Physiol. 38 297 PMID: 18264777
Dasgupta et al (2010) Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc.Natl.Acad.Sci. 103 6332
If you know of a relevant reference for Hexamethonium bromide, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Hexamethonium bromide, Hexamethonium bromide supplier, Hexamethonium, Br, nicotinic, receptor, blocker, ganglion, nAChR, antagonist, Nicotinic, Receptors, (Non-selective), 4111, Tocris Bioscience
Citations for Hexamethonium bromide
Citations are publications that use Tocris products.
Currently there are no citations for Hexamethonium bromide. Do you know of a great paper that uses Hexamethonium bromide from Tocris? Please let us know.
Reviews for Hexamethonium bromide
Average Rating: 5 (Based on 1 Review.)
Have you used Hexamethonium bromide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
This is a fantastic drug for examining nicotinic receptor effects. It is easy to work with for slice recordings and washes out nicely. We typically use 50-200uM concentrations.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.