Hexamethonium bromide

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Cat.No. 4111 - Hexamethonium bromide | C12H30Br2N2 | CAS No. 55-97-0
Description: Non-competitive nAChR antagonist
Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide
Reviews (1)
Literature (3)

Biological Activity

Nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.

Technical Data

M. Wt 362.19
Formula C12H30Br2N2
Storage Desiccate at RT
CAS Number 55-97-0
PubChem ID 5938
Smiles C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 36.22 100
DMSO 18.11 50

Preparing Stock Solutions

The following data is based on the product molecular weight 362.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.61 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References are publications that support the biological activity of the product.

Karavaev et al (2008) The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro. Neurosci.Behav.Physiol. 38 297 PMID: 18264777

Dasgupta et al (2010) Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc.Natl.Acad.Sci. 103 6332

If you know of a relevant reference for Hexamethonium bromide, please let us know.

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Citations for Hexamethonium bromide

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Reviews for Hexamethonium bromide

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Nicotinic blocker for decreasing stimulated dopamine release.
By Anonymous on 05/15/2018
Assay Type: Ex Vivo
Species: Mouse

This is a fantastic drug for examining nicotinic receptor effects. It is easy to work with for slice recordings and washes out nicely. We typically use 50-200uM concentrations.

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Literature in this Area

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Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

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Nicotinic ACh Receptors

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.


Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.