HDS 029

Discontinued Product

HDS 029 (Cat. No. 2646) has been withdrawn from sale for commercial reasons.
Cat.No. 2646 - HDS 029 | C17H11ClFN5O | CAS No. 881001-19-0
Description: Potent inhibitor of the ErbB receptor family
Chemical Name: N-(4-[(-3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl-2-butynamide
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent inhibitor of the ErbB receptor family (IC50 values are 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2 respectively). Inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 values are 2.5 and 24 nM respectively).

Technical Data

M. Wt 355.76
Formula C17H11ClFN5O
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 881001-19-0
PubChem ID 11566580
InChI Key DLPSDPPZXRJQOY-UHFFFAOYSA-N
Smiles FC(C=C3)=C(Cl)C=C3NC1=NC=NC2=C1C=C(NC(C#CC)=O)N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

References

References are publications that support the biological activity of the product.

Klutchko et al (2006) Tyrosine kinase inhibitors. 19. 6-alkynamides of 4-anilinoquinazolines and 4-aniliopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J.Med.Chem. 49 1475 PMID: 16480284

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Keywords: HDS 029, HDS 029 supplier, Potent, inhibitors, inhibits, ErbB, receptor, family, Epidermal, Growth, Factors, Receptors, Her, EGFR, Receptor, Tyrosine, Kinases, RTKs, HDS029, 2646, Tocris Bioscience

1 Citation for HDS 029

Citations are publications that use Tocris products. Selected citations for HDS 029 include:

Watanabe et al (2011) A novel glycosylation signal regulates transforming growth factor beta receptors as evidenced by endo-beta-galactosidase C expression in rodent cells. Glycobiology 21 482 PMID: 21062784


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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