HDS 029

Pricing Availability Delivery Time Qty
Cat.No. 2646 - HDS 029 | C17H11ClFN5O | CAS No. 881001-19-0
Description: Potent inhibitor of the ErbB receptor family
Chemical Name: N-(4-[(-3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl-2-butynamide
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent inhibitor of the ErbB receptor family (IC50 values are 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2 respectively). Inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 values are 2.5 and 24 nM respectively).

Technical Data

M. Wt 355.76
Formula C17H11ClFN5O
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 881001-19-0
PubChem ID 11566580
InChI Key DLPSDPPZXRJQOY-UHFFFAOYSA-N
Smiles FC(C=C3)=C(Cl)C=C3NC1=NC=NC2=C1C=C(NC(C#CC)=O)N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.89 25

Preparing Stock Solutions

The following data is based on the product molecular weight 355.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.05 mL 28.11 mL
5 mM 0.56 mL 2.81 mL 5.62 mL
10 mM 0.28 mL 1.41 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Klutchko et al (2006) Tyrosine kinase inhibitors. 19. 6-alkynamides of 4-anilinoquinazolines and 4-aniliopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J.Med.Chem. 49 1475 PMID: 16480284


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1 Citation for HDS 029

Citations are publications that use Tocris products. Selected citations for HDS 029 include:

Watanabe et al (2011) A novel glycosylation signal regulates transforming growth factor beta receptors as evidenced by endo-beta-galactosidase C expression in rodent cells. Glycobiology 21 482 PMID: 21062784


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Pathways for HDS 029

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