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STING antagonist. Covalently binds STING at Cys91, blocking palmitoylation and preventing assembly of STING clusters. Decreases inflammatory cytokine production in human and mouse cells in vitro. Also blocks CMA (Cat. No. 6677) -induced increases in levels of inflammatory cytokines in mice, and alleviates systemic inflammation in a mouse model of autoinflammatory disease.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 279.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.58 mL||17.9 mL||35.8 mL|
|5 mM||0.72 mL||3.58 mL||7.16 mL|
|10 mM||0.36 mL||1.79 mL||3.58 mL|
|50 mM||0.07 mL||0.36 mL||0.72 mL|
References are publications that support the biological activity of the product.
Haag et al (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559 269 PMID: 29973723
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Keywords: H 151, H 151 supplier, H151, STING, antagonist, antagonism, anti-inflammatory, covalent, STING-Dependent, Signaling, 6675, Tocris Bioscience
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