H 151

Pricing Availability   Qty
Description: STING antagonist
Chemical Name: N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for H 151

H 151 is a STING antagonist. Covalently binds STING at Cys91, blocking palmitoylation and preventing assembly of STING clusters. Decreases inflammatory cytokine production in human and mouse cells in vitro. Also blocks CMA (Cat. No. 6677) -induced increases in levels of inflammatory cytokines in mice, and alleviates systemic inflammation in a mouse model of autoinflammatory disease.

Compound Libraries for H 151

H 151 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for H 151

M. Wt 279.34
Formula C17H17N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 941987-60-6
PubChem ID 7616033
Smiles CCC1=CC=C(C=C1)NC(NC2=CNC3=CC=CC=C23)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for H 151

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.93 100
ethanol 13.97 50

Preparing Stock Solutions for H 151

The following data is based on the product molecular weight 279.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.9 mL 35.8 mL
5 mM 0.72 mL 3.58 mL 7.16 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets for H 151

Certificate of Analysis / Product Datasheet
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References for H 151

References are publications that support the biological activity of the product.

Haag et al (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559 269 PMID: 29973723

If you know of a relevant reference for H 151, please let us know.

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Keywords: H 151, H 151 supplier, H151, STING, antagonist, antagonism, anti-inflammatory, covalent, STING-Dependent, Signaling, 6675, Tocris Bioscience

2 Citations for H 151

Citations are publications that use Tocris products. Selected citations for H 151 include:

Kevin C et al (2023) Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies. J Exp Med 220 PMID: 36534085

Ying et al (2023) STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity. Adv Sci (Weinh) 10 e2203718 PMID: 36445063

Do you know of a great paper that uses H 151 from Tocris? Please let us know.

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