H 151

Pricing Availability   Qty
Cat.No. 6675 - H 151 | C17H17N3O | CAS No. 941987-60-6
Description: STING antagonist
Chemical Name: N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

STING antagonist. Covalently binds STING at Cys91, blocking palmitoylation and preventing assembly of STING clusters. Decreases inflammatory cytokine production in human and mouse cells in vitro. Also blocks CMA (Cat. No. 6677) -induced increases in levels of inflammatory cytokines in mice, and alleviates systemic inflammation in a mouse model of autoinflammatory disease.

Technical Data

M. Wt 279.34
Formula C17H17N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 941987-60-6
PubChem ID 7616033
InChI Key UJZDIKVQFMCLBE-UHFFFAOYSA-N
Smiles CCC1=CC=C(C=C1)NC(NC2=CNC3=CC=CC=C23)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.93 100
ethanol 13.97 50

Preparing Stock Solutions

The following data is based on the product molecular weight 279.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.9 mL 35.8 mL
5 mM 0.72 mL 3.58 mL 7.16 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Haag et al (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559 269 PMID: 29973723


If you know of a relevant reference for H 151, please let us know.

View Related Products by Target

View Related Products by Product Action

View all STING-Dependent Signaling Antagonists

Keywords: H 151, H 151 supplier, H151, STING, antagonist, antagonism, anti-inflammatory, covalent, STING-Dependent, Signaling, 6675, Tocris Bioscience

Citations for H 151

Citations are publications that use Tocris products.

Currently there are no citations for H 151. Do you know of a great paper that uses H 151 from Tocris? Please let us know.

Reviews for H 151

There are currently no reviews for this product. Be the first to review H 151 and earn rewards!

Have you used H 151?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation