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Biological Activity for CMA
CMA is a STING agonist; murine-selective (Kd = 3.5 μM). Triggers type I IFN response in murine macrophages, with no effect on human STING signaling.
Compound Libraries for CMA
Technical Data for CMA
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CMA
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CMA
The following data is based on the product molecular weight 253.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.95 mL||19.74 mL||39.49 mL|
|5 mM||0.79 mL||3.95 mL||7.9 mL|
|10 mM||0.39 mL||1.97 mL||3.95 mL|
|50 mM||0.08 mL||0.39 mL||0.79 mL|
References for CMA
References are publications that support the biological activity of the product.
Haag et al (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559 269 PMID: 29973723
Cavlar et al (2013) Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 32 1440 PMID: 23604073
Zhang et al (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci. Rep. 5 18035 PMID: 26669264
If you know of a relevant reference for CMA, please let us know.
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Keywords: CMA, CMA supplier, Murine-selective, STING, agonists, agonism, STING-Dependent, Signaling, 6677, Tocris Bioscience
1 Citation for CMA
Citations are publications that use Tocris products. Selected citations for CMA include:
Jie et al (2023) Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome. iScience 26 106758 PMID: 37216118
Do you know of a great paper that uses CMA from Tocris? Please let us know.
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