CMA

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Cat.No. 6677 - CMA | C15H11NO3 | CAS No. 38609-97-1
Description: Murine-selective STING agonist
Chemical Name: 9-Oxo-10(9H)-acridineacetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

STING agonist; murine-selective (Kd = 3.5 μM). Triggers type I IFN response in murine macrophages, with no effect on human STING signaling.

Technical Data

M. Wt 253.25
Formula C15H11NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 38609-97-1
PubChem ID 38072
InChI Key UOMKBIIXHQIERR-UHFFFAOYSA-N
Smiles OC(CN1C2=CC=CC=C2C(C3=C1C=CC=C3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 253.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.95 mL 19.74 mL 39.49 mL
5 mM 0.79 mL 3.95 mL 7.9 mL
10 mM 0.39 mL 1.97 mL 3.95 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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References

References are publications that support the biological activity of the product.

Haag et al (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559 269 PMID: 29973723

Cavlar et al (2013) Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 32 1440 PMID: 23604073

Zhang et al (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci. Rep. 5 18035 PMID: 26669264


If you know of a relevant reference for CMA, please let us know.

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Keywords: CMA, CMA supplier, Murine-selective, STING, agonists, agonism, STING-Dependent, Signaling, 6677, Tocris Bioscience

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Literature in this Area

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