GYY 4137 morpholine salt

Pricing Availability   Qty
Description: Slow-releasing H2S donor
Chemical Name: P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt
Citations (1)

Biological Activity for GYY 4137 morpholine salt

GYY 4137 morpholine salt is a slow-releasing H2S donor. Exhibits vasodilator and antihypertensive activity. Activity causes slow dilation of blood vessels in vitro and in vivo; does not influence vascular smooth muscle cell viability in culture. Water-soluble.

Technical Data for GYY 4137 morpholine salt

M. Wt 376.47
Formula C11H16NO2PS2.C4H9NO
Storage Store at -20°C
CAS Number 106740-09-4
PubChem ID 46937261

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GYY 4137 morpholine salt

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.65 100

Preparing Stock Solutions for GYY 4137 morpholine salt

The following data is based on the product molecular weight 376.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.28 mL 26.56 mL
5 mM 0.53 mL 2.66 mL 5.31 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets for GYY 4137 morpholine salt

References for GYY 4137 morpholine salt

References are publications that support the biological activity of the product.

Li et al (2008) Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137). Circulation 117 2351 PMID: 18443240

Whiteman et al (2010) The effect of hydrogen sulfide donors on lipopolysaccaride-induced formation of inflammatory mediators in macrophages. Antioxid.Redox.Signal. 12 1147 PMID: 19769459

Lee et al (2011) The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One 6 e21077 PMID: 21701688

Liu et al (2013) Hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E-/- mice. Br.J.Pharmacol. [Epub ahead of print] PMID: 23713790

If you know of a relevant reference for GYY 4137 morpholine salt, please let us know.

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1 Citation for GYY 4137 morpholine salt

Citations are publications that use Tocris products. Selected citations for GYY 4137 morpholine salt include:

Y S et al (2020) Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle. FASEB J 34 12991-13004 PMID: 32777143

Do you know of a great paper that uses GYY 4137 morpholine salt from Tocris? Please let us know.

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