GYY 4137 morpholine salt

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Cat.No. 3658 - GYY 4137 morpholine salt | C11H16NO2PS2.C4H9NO | CAS No. 106740-09-4
Description: Slow-releasing H2S donor
Chemical Name: P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt
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Biological Activity

Slow-releasing H2S donor. Exhibits vasodilator and antihypertensive activity. Activity causes slow dilation of blood vessels in vitro and in vivo; does not influence vascular smooth muscle cell viability in culture. Water-soluble.

Technical Data

M. Wt 376.47
Formula C11H16NO2PS2.C4H9NO
Storage Store at -20°C
CAS Number 106740-09-4
PubChem ID 46937261
InChI Key YZMHNNLDUWRZFW-UHFFFAOYSA-N
Smiles S=P(N1CCOCC1)(C2=CC=C(OC)C=C2)S.N3CCOCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 376.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.28 mL 26.56 mL
5 mM 0.53 mL 2.66 mL 5.31 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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References

References are publications that support the biological activity of the product.

Li et al (2008) Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137). Circulation 117 2351 PMID: 18443240

Whiteman et al (2010) The effect of hydrogen sulfide donors on lipopolysaccaride-induced formation of inflammatory mediators in macrophages. Antioxid.Redox.Signal. 12 1147 PMID: 19769459

Lee et al (2011) The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One 6 e21077 PMID: 21701688

Liu et al (2013) Hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E-/- mice. Br.J.Pharmacol. [Epub ahead of print] PMID: 23713790


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