GW 542573X

Pricing Availability Delivery Time Qty
Cat.No. 4311 - GW 542573X | C19H28N2O5 | CAS No. 660846-41-3
Description: Selective activator of KCa2.1 channels
Chemical Name: 4-[[[[(2-Methoxyphenyl)amino]carbonyl]oxy]methyl]-piperidinecarboxylic acid-1,1-dimethylethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Activator of small-conductance Ca2+-activated K+ channels (KCa2); selective for KCa2.1 (EC50 = 8.2 μM in HEK293 cells expressing hKCa2.1) with the profile hKCa2.1 > hKCa2.2 = hKCa2.3 > hKCa3.1 (IK).

Compound Libraries

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Technical Data

M. Wt 364.44
Formula C19H28N2O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 660846-41-3
PubChem ID 24885053
InChI Key SAXGSDIZIYFNKD-UHFFFAOYSA-N
Smiles O=C(OC(C)(C)C)N1CCC(COC(NC2=CC=CC=C2OC)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.44 100
ethanol 36.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 364.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hougaard et al (2009) Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methyoxy-phenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 298 in Mol.Pharmacol. 76 569 PMID: 19515965


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