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Submit ReviewGW 311616 hydrochloride
Discontinued Product
GW 311616 hydrochloride (Cat. No. 1959) has been withdrawn from sale for commercial reasons.
Description: Potent, selective human leukocyte elastase inhibitor
Chemical Name: (3S,3aS,6aR)-Hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-butenyl]pyrrolo[3,2-b]pyrrol-2(1H)-one
Purity: ≥98% (HPLC)
Biological Activity
Potent and selective inhibitor of human leukocyte elastase (HLE) (IC50 = 22 nM); displays > 4500-fold selectivity over other human serine proteases. Orally active in vivo.
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline.
Technical Data
| M. Wt | 433.99 |
| Formula | C19H31N3O4S.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 198062-54-3 |
| Smiles | O=C(/C=C/CN2CCCCC2)N1CC[C@](N3S(=O)(C)=O)([H])[C@@]([H])1C(C(C)C)C3=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Macdonald et al (2001) The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase - GW311616A a development candidate. Bioorg.Med.Chem.Lett. 11 895 PMID: 11294386
Ohbayashi (2002) Neutrophil elastase inhibitors as treatment for COPD. Exp.Opin.Investig.Drugs 11 965 PMID: 12084007
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Citations for GW 311616 hydrochloride
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Currently there are no citations for GW 311616 hydrochloride.
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