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GW 311616 hydrochloride

Cat. No. 1959 Submit a Review Datasheet / COA / SDS

Discontinued Product

GW 311616 hydrochloride (Cat. No. 1959) has been withdrawn from sale for commercial reasons.
Cat.No. 1959 - GW 311616 hydrochloride | C19H31N3O4S.HCl | CAS No. 198062-54-3
Description: Potent, selective human leukocyte elastase inhibitor
Chemical Name: (3S,3aS,6aR)-Hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-butenyl]pyrrolo[3,2-b]pyrrol-2(1H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Biological Activity Technical Data Datasheets References

Biological Activity

Potent and selective inhibitor of human leukocyte elastase (HLE) (IC50 = 22 nM); displays > 4500-fold selectivity over other human serine proteases. Orally active in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M. Wt 433.99
Formula C19H31N3O4S.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 198062-54-3
Smiles O=C(/C=C/CN2CCCCC2)N1CC[C@](N3S(=O)(C)=O)([H])[C@@]([H])1C(C(C)C)C3=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Macdonald et al (2001) The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase - GW311616A a development candidate. Bioorg.Med.Chem.Lett. 11 895 PMID: 11294386

Ohbayashi (2002) Neutrophil elastase inhibitors as treatment for COPD. Exp.Opin.Investig.Drugs 11 965 PMID: 12084007

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Citations for GW 311616 hydrochloride

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