Home / Pharmacology / Enzymes / Proteases / Elastases / Elastase Inhibitors / GW 311616 hydrochloride

GW 311616 hydrochloride

Cat. No. 1959 COA / Product Datasheet SDS

Discontinued Product

Unfortunately GW 311616 hydrochloride (Cat. No. 1959) has been withdrawn from sale for commercial reasons.
Cat.No. 1959 - GW 311616 hydrochloride | C19H31N3O4S.HCl | CAS No. 198062-54-3
Description: Potent, selective human leukocyte elastase inhibitor
Chemical Name: (3S,3aS,6aR)-Hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-butenyl]pyrrolo[3,2-b]pyrrol-2(1H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Biological Activity Technical Data Datasheets References

Biological Activity

Potent and selective inhibitor of human leukocyte elastase (HLE) (IC50 = 22 nM); displays > 4500-fold selectivity over other human serine proteases. Orally active in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M. Wt 433.99
Formula C19H31N3O4S.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 198062-54-3
Smiles O=C(/C=C/CN2CCCCC2)N1CC[C@](N3S(=O)(C)=O)([H])[C@@]([H])1C(C(C)C)C3=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the products' biological activity.

Macdonald et al (2001) The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase - GW311616A a development candidate. Bioorg.Med.Chem.Lett. 11 895 PMID: 11294386

Ohbayashi (2002) Neutrophil elastase inhibitors as treatment for COPD. Exp.Opin.Investig.Drugs 11 965 PMID: 12084007

View Related Products by Target

View Related Products by Product Action

View all Elastase Inhibitors

Keywords: GW 311616 hydrochloride, supplier, Potent, selective, human, leukocyte, elastase, inhibitors, inhibits, Neutrophil, Proteinases, Proteases, GW311616, hydrochloride, GlaxoSmithKline, Elastase, Elastase, Tocris Bioscience

Citations for GW 311616 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for GW 311616 hydrochloride.

Reviews for GW 311616 hydrochloride

There are currently no reviews for this product. Be the first to review GW 311616 hydrochloride and earn rewards!

Have you used GW 311616 hydrochloride?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells