GW 311616 hydrochloride
Discontinued ProductUnfortunately GW 311616 hydrochloride (Cat. No. 1959) has been withdrawn from sale for commercial reasons.
Potent and selective inhibitor of human leukocyte elastase (HLE) (IC50 = 22 nM); displays > 4500-fold selectivity over other human serine proteases. Orally active in vivo.
Sold for research purposes under agreement from GlaxoSmithKline.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 433.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.3 mL||11.52 mL||23.04 mL|
|5 mM||0.46 mL||2.3 mL||4.61 mL|
|10 mM||0.23 mL||1.15 mL||2.3 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References are publications that support the products' biological activity.
Macdonald et al (2001) The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase - GW311616A a development candidate. Bioorg.Med.Chem.Lett. 11 895 PMID: 11294386
Ohbayashi (2002) Neutrophil elastase inhibitors as treatment for COPD. Exp.Opin.Investig.Drugs 11 965 PMID: 12084007
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Citations for GW 311616 hydrochloride
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