Home / Pharmacology / Enzymes / Proteases / Elastases / Elastase Inhibitors / GW 311616 hydrochloride

GW 311616 hydrochloride

Cat. No. 1959 Submit a Review Datasheet / COA / SDS

Discontinued Product

GW 311616 hydrochloride (Cat. No. 1959) has been withdrawn from sale for commercial reasons.
Cat.No. 1959 - GW 311616 hydrochloride | C19H31N3O4S.HCl | CAS No. 198062-54-3
Description: Potent, selective human leukocyte elastase inhibitor
Chemical Name: (3S,3aS,6aR)-Hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-butenyl]pyrrolo[3,2-b]pyrrol-2(1H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Datasheets References

Biological Activity

Potent and selective inhibitor of human leukocyte elastase (HLE) (IC50 = 22 nM); displays > 4500-fold selectivity over other human serine proteases. Orally active in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M. Wt 433.99
Formula C19H31N3O4S.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 198062-54-3
Smiles O=C(/C=C/CN2CCCCC2)N1CC[C@](N3S(=O)(C)=O)([H])[C@@]([H])1C(C(C)C)C3=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Macdonald et al (2001) The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase - GW311616A a development candidate. Bioorg.Med.Chem.Lett. 11 895 PMID: 11294386

Ohbayashi (2002) Neutrophil elastase inhibitors as treatment for COPD. Exp.Opin.Investig.Drugs 11 965 PMID: 12084007

View Related Products by Target

View Related Products by Product Action

View all Elastase Inhibitors

Keywords: GW 311616 hydrochloride, GW 311616 hydrochloride supplier, Potent, selective, human, leukocyte, elastase, inhibitors, inhibits, Neutrophil, Proteinases, Proteases, GW311616, hydrochloride, GlaxoSmithKline, Elastase, 1959, Tocris Bioscience

Citations for GW 311616 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for GW 311616 hydrochloride.

Reviews for GW 311616 hydrochloride

There are currently no reviews for this product. Be the first to review GW 311616 hydrochloride and earn rewards!

Have you used GW 311616 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells