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Submit ReviewGW 311616 hydrochloride
Description: Potent, selective human leukocyte elastase inhibitor
Chemical Name: (3S,3aS,6aR)-Hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-butenyl]pyrrolo[3,2-b]pyrrol-2(1H)-one
Purity: ≥98% (HPLC)
Biological Activity for GW 311616 hydrochloride
Potent and selective inhibitor of human leukocyte elastase (HLE) (IC50 = 22 nM); displays > 4500-fold selectivity over other human serine proteases. Orally active in vivo.
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline.
Technical Data for GW 311616 hydrochloride
| M. Wt | 433.99 |
| Formula | C19H31N3O4S.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 198062-54-3 |
| Smiles | O=C(/C=C/CN2CCCCC2)N1CC[C@](N3S(=O)(C)=O)([H])[C@@]([H])1C(C(C)C)C3=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GW 311616 hydrochloride
References for GW 311616 hydrochloride
References are publications that support the biological activity of the product.
Macdonald et al (2001) The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase - GW311616A a development candidate. Bioorg.Med.Chem.Lett. 11 895 PMID: 11294386
Ohbayashi (2002) Neutrophil elastase inhibitors as treatment for COPD. Exp.Opin.Investig.Drugs 11 965 PMID: 12084007
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Citations for GW 311616 hydrochloride
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