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Biological Activity for Gue 1654
Gue 1654 is an oxoeicosanoid receptor 1 (OXE-R) modulator. Selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells.
Technical Data for Gue 1654
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Gue 1654
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Gue 1654
The following data is based on the product molecular weight 447.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.47 mL||22.34 mL||44.68 mL|
|2.5 mM||0.89 mL||4.47 mL||8.94 mL|
|5 mM||0.45 mL||2.23 mL||4.47 mL|
|25 mM||0.09 mL||0.45 mL||0.89 mL|
References for Gue 1654
References are publications that support the biological activity of the product.
Blättermann et al (2012) A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer Nat.Chem.Biol. 8 631 PMID: 22634634
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1 Citation for Gue 1654
Citations are publications that use Tocris products. Selected citations for Gue 1654 include:
Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID: 28954865
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Literature in this Area
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