Gue 1654

Pricing Availability   Qty
Cat.No. 4742 - Gue 1654 | C23H17N3OS3 | CAS No. 397290-30-1
Description: Selective inhibitor of OXE-R Gβ/γ signaling
Chemical Name: N-[7-(Methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenylbenzeneacetamide
Purity: ≥97% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Gue 1654

Gue 1654 is an oxoeicosanoid receptor 1 (OXE-R) modulator. Selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells.

Technical Data for Gue 1654

M. Wt 447.6
Formula C23H17N3OS3
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 397290-30-1
PubChem ID 5066134
Smiles O=C(C(C5=CC=CC=C5)C4=CC=CC=C4)NC(S3)=NC1=C3C(SC(SC)=N2)=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Gue 1654

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.38 50

Preparing Stock Solutions for Gue 1654

The following data is based on the product molecular weight 447.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.47 mL 22.34 mL 44.68 mL
2.5 mM 0.89 mL 4.47 mL 8.94 mL
5 mM 0.45 mL 2.23 mL 4.47 mL
25 mM 0.09 mL 0.45 mL 0.89 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Gue 1654

References are publications that support the biological activity of the product.

Blättermann et al (2012) A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer Nat.Chem.Biol. 8 631 PMID: 22634634

If you know of a relevant reference for Gue 1654, please let us know.

View Related Products by Product Action

View all Heterotrimeric G-protein GTPase Inhibitors

Keywords: Gue 1654, Gue 1654 supplier, Gue1654, OXE-R, modulators, inhibitors, inhibits, selective, beta, gamma, β, γ, signalling, signaling, heterotrimeric, G-proteins, oxeiocosanoid, receptors, Heterotrimeric, G-protein, GTPases, Leukotriene, and, Related, Receptors, 4742, Tocris Bioscience

1 Citation for Gue 1654

Citations are publications that use Tocris products. Selected citations for Gue 1654 include:

Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID: 28954865

Do you know of a great paper that uses Gue 1654 from Tocris? Please let us know.

Reviews for Gue 1654

There are currently no reviews for this product. Be the first to review Gue 1654 and earn rewards!

Have you used Gue 1654?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling