Gue 1654

Pricing Availability Delivery Time Qty
Cat.No. 4742 - Gue 1654 | C23H17N3OS3 | CAS No. 397290-30-1
Description: Selective inhibitor of OXE-R Gβγ signaling
Chemical Name: N-[7-(Methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenylbenzeneacetamide
Purity: ≥97% (HPLC)

Biological Activity

Oxoeicosanoid receptor 1 (OXE-R) modulator. Selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells.

Compound Libraries

Gue 1654 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 447.6
Formula C23H17N3OS3
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 397290-30-1
PubChem ID 5066134
Smiles O=C(C(C5=CC=CC=C5)C4=CC=CC=C4)NC(S3)=NC1=C3C(SC(SC)=N2)=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.38 50

Preparing Stock Solutions

The following data is based on the product molecular weight 447.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.17 mL 22.34 mL
5 mM 0.45 mL 2.23 mL 4.47 mL
10 mM 0.22 mL 1.12 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Blättermann et al (2012) A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer Nat.Chem.Biol. 8 631 PMID: 22634634

If you know of a relevant reference for Gue 1654, please let us know.

View Related Products by Product Action

View all G Protein (Heterotrimeric) Inhibitors

Keywords: Gue1654 OXE-R modulators inhibitors inhibits selective beta gamma β γ signalling signaling heterotrimeric G-proteins oxeiocosanoid receptors G Protein (Heterotrimeric)

Citations for Gue 1654

Citations are publications that use Tocris products.

Currently there are no citations for Gue 1654. Do you know of a great paper that uses Gue 1654 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling

Pathways for Gue 1654


TODO: Add Protocols