Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGT 2016
Discontinued Product
2419 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
Description: Selective H3 antagonist
Chemical Name: 5-Cyclohexyl-1-[4-(1H-imidazol-5-yl)-1-piperidinyl]-1-pentanone
Purity: ≥98% (HPLC)
Biological Activity for GT 2016
GT 2016 is a high affinity H3 receptor antagonist (Ki = 43.8 nM). Displays selectivity against H1 and H2 receptors (IC50 >10 μM). Increases the release of histamine in the cerebral cortex. Displays no activity at histamine methyltransferase in vitro at concentrations up to 3 μM. Brain penetrant.
Technical Data for GT 2016
| M. Wt | 317.47 |
| Formula | C19H31N3O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 152241-24-2 |
| PubChem ID | 9839975 |
| InChI Key | YTCGNPGLMAECND-UHFFFAOYSA-N |
| Smiles | O=C(CCCCC3CCCCC3)N(CC2)CCC2C1=CN=CN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GT 2016
References for GT 2016
References are publications that support the biological activity of the product.
Tedford et al (1995) Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies. J.Pharmacol.Exp.Ther. 275 598 PMID: 7473144
Tedford et al (1999) Development of trans-2-[1H-imidazol-4-yl] cyclopropane derivatives as new high-affinity histamine H3 receptor ligands. J.Pharmacol.Exp.Ther. 289 1160 PMID: 10215700
Yates et al (1999) Identification and pharmacological characterization of a series of new 1H-4-substituted-imidazoyl histamine H3 receptor ligands. J.Pharmacol.Exp.Ther. 289 1151 PMID: 10215699
View Related Products by Target
View Related Products by Product Action
Keywords: GT 2016, GT 2016 supplier, GT2016, histamine, h3, antagonists, histaminergic, selective, brain, penetrant, centrally, active, Histamine, H3, Receptors, 2419, Tocris Bioscience
Citations for GT 2016
Citations are publications that use Tocris products.
Currently there are no citations for GT 2016.
Reviews for GT 2016
There are currently no reviews for this product. Be the first to review GT 2016 and earn rewards!
Have you used GT 2016?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.