GSK LSD 1 dihydrochloride

Pricing Availability   Qty
Description: Potent and selective LSD1 inhibitor
Chemical Name: rel-N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine dihydrochloride
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for GSK LSD 1 dihydrochloride

GSK LSD 1 dihydrochloride is a potent and selective lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 16 nM). Exhibits >1000-fold selectivity for LSD1 over closely related enzymes including LSD2, MAO-1 and MAO-B. Inhibits cancer cell line growth in vitro.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK LSD 1 probe summary on the SGC website.

Compound Libraries for GSK LSD 1 dihydrochloride

GSK LSD 1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK LSD 1 dihydrochloride

M. Wt 289.24
Formula C14H20N2.2HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2102933-95-7
PubChem ID 91663353
Smiles C1(N[C@@H]2C[C@H]2[C@]3=CC=CC=C3)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK LSD 1 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 28.92 100
DMSO 28.92 100

Preparing Stock Solutions for GSK LSD 1 dihydrochloride

The following data is based on the product molecular weight 289.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.46 mL 17.29 mL 34.57 mL
5 mM 0.69 mL 3.46 mL 6.91 mL
10 mM 0.35 mL 1.73 mL 3.46 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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Product Datasheets for GSK LSD 1 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for GSK LSD 1 dihydrochloride

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Citations for GSK LSD 1 dihydrochloride

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Literature in this Area

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