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Submit ReviewGSK LSD 1 dihydrochloride
Description: Potent and selective LSD1 inhibitor
Chemical Name: rel-N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for GSK LSD 1 dihydrochloride
GSK LSD 1 dihydrochloride is a potent and selective lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 16 nM). Exhibits >1000-fold selectivity for LSD1 over closely related enzymes including LSD2, MAO-1 and MAO-B. Inhibits cancer cell line growth in vitro.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK LSD 1 probe summary on the SGC website.
Compound Libraries for GSK LSD 1 dihydrochloride
GSK LSD 1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for GSK LSD 1 dihydrochloride
| M. Wt | 289.24 |
| Formula | C14H20N2.2HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2102933-95-7 |
| PubChem ID | 91663353 |
| InChI Key | PJFZOGMSPBHPNS-WICJZZOFSA-N |
| Smiles | C1(N[C@@H]2C[C@H]2[C@]3=CC=CC=C3)CCNCC1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GSK LSD 1 dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 28.92 | 100 | |
| DMSO | 28.92 | 100 |
Preparing Stock Solutions for GSK LSD 1 dihydrochloride
The following data is based on the product molecular weight 289.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.46 mL | 17.29 mL | 34.57 mL |
| 5 mM | 0.69 mL | 3.46 mL | 6.91 mL |
| 10 mM | 0.35 mL | 1.73 mL | 3.46 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
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Product Datasheets for GSK LSD 1 dihydrochloride
References for GSK LSD 1 dihydrochloride
References are publications that support the biological activity of the product.
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Keywords: GSK LSD 1 dihydrochloride, GSK LSD 1 dihydrochloride supplier, GSKLSD1, dihydrochloride, potent, selective, lysine, specific, demethylases, LSD1, inhibitors, inhibits, SGC, structural, genomics, consortium, histone, Histone, Demethylases, 5361, Tocris Bioscience
1 Citation for GSK LSD 1 dihydrochloride
Citations are publications that use Tocris products. Selected citations for GSK LSD 1 dihydrochloride include:
Ping et al (2022) Targeting histone demethylase LSD1 for treatment of deficits in autism mouse models. Mol Psychiatry 27 3355-3366 PMID: 35296809
Do you know of a great paper that uses GSK LSD 1 dihydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.