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GSK LSD 1 dihydrochloride
Biological Activity for GSK LSD 1 dihydrochloride
GSK LSD 1 dihydrochloride is a potent and selective lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 16 nM). Exhibits >1000-fold selectivity for LSD1 over closely related enzymes including LSD2, MAO-1 and MAO-B. Inhibits cancer cell line growth in vitro.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK LSD 1 probe summary on the SGC website.
Compound Libraries for GSK LSD 1 dihydrochloride
Technical Data for GSK LSD 1 dihydrochloride
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GSK LSD 1 dihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GSK LSD 1 dihydrochloride
The following data is based on the product molecular weight 289.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.46 mL||17.29 mL||34.57 mL|
|5 mM||0.69 mL||3.46 mL||6.91 mL|
|10 mM||0.35 mL||1.73 mL||3.46 mL|
|50 mM||0.07 mL||0.35 mL||0.69 mL|
Product Datasheets for GSK LSD 1 dihydrochloride
References for GSK LSD 1 dihydrochloride
References are publications that support the biological activity of the product.
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Citations for GSK LSD 1 dihydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases