GSK LSD 1 dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 5361 - GSK LSD 1 dihydrochloride | C14H20N2.2HCl
Description: Potent and selective LSD1 inhibitor
Chemical Name: rel-N-[(1S,2R)-2-Phenylcyclopropyl]-4-piperidinamine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 16 nM). Exhibits >1000-fold selectivity for LSD1 over closely related enzymes including LSD2, MAO-1 and MAO-B. Inhibits cancer cell line growth in vitro.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK LSD 1 probe summary on the SGC website.

Compound Libraries

GSK LSD 1 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 289.24
Formula C14H20N2.2HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 91663353
InChI Key PJFZOGMSPBHPNS-WICJZZOFSA-N
Smiles C1(N[C@@H]2C[C@H]2[C@]3=CC=CC=C3)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.92 100
water 28.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 289.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.46 mL 17.29 mL 34.57 mL
5 mM 0.69 mL 3.46 mL 6.91 mL
10 mM 0.35 mL 1.73 mL 3.46 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

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Citations for GSK LSD 1 dihydrochloride

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases