GSK 923295A

Discontinued Product

GSK 923295A (Cat. No. 6837) has been withdrawn from sale for commercial reasons.
Description: Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor
Chemical Name: 3-Chloro-N-[(1S)-2-[[2-(dimethylamino)acetyl]amino]-1-[[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]methyl]ethyl]-4-(1-methylethoxy)benzamide
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for GSK 923295A

GSK 923295A is a potent and selective centromere associated protein E (CENP-E) allosteric inhibitor (IC50 = 22 nM); does not compete with ATP. Exhibits selectivity over a panel of other kinesins (<25% inhibition at 50 μM). Inhibits tumor cell growth in vitro. Induces mitotic arrest and regression of human tumor xenografts in vivo.

Technical Data for GSK 923295A

M. Wt 592.13
Formula C32H38ClN5O4
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1088965-37-0
PubChem ID 46898058
InChI Key WHMXDBPHBVLYRC-OFVILXPXSA-N
Smiles CC(OC1=C(C=C(C(N[C@@H](CC2=CC=C(C3=CN4C=CC=C(C4=N3)[C@@H](O)C)C=C2)CNC(CN(C)C)=O)=O)C=C1)Cl)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for GSK 923295A

References are publications that support the biological activity of the product.

Qian et al (2010) Discovery of the first potent and selective inhibitor of centromere-associated protein E: GSK923295. ACS Med.Chem.Lett. 1 30 PMID: 24900171

Wood et al (2010) Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc.Natl.Acad.Sci.U.S.A. 107 5839 PMID: 20167803

View Related Products by Target

View Related Products by Product Action

View all Kinesin Inhibitors

Keywords: GSK 923295A, GSK 923295A supplier, GSK923295A, ATPase, Potent, selective, centromere, associated, protein, E, CENP-E, allosteric, inhibitors, inhibits, mitotic, kinesin, mitosis, Kinesin, 6837, Tocris Bioscience

Citations for GSK 923295A

Citations are publications that use Tocris products.

Currently there are no citations for GSK 923295A.

Reviews for GSK 923295A

There are currently no reviews for this product. Be the first to review GSK 923295A and earn rewards!

Have you used GSK 923295A?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets