Potent LXR antagonist (pIC50 = 7.5). Enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. Cell permeable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 591.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.69 mL||8.45 mL||16.9 mL|
|5 mM||0.34 mL||1.69 mL||3.38 mL|
|10 mM||0.17 mL||0.85 mL||1.69 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
References are publications that support the products' biological activity.
Zuercher et al (2010) Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J.Med.Chem. 53 3412 PMID: 20345102
Solt et al (2012) LXR-mediated inhibition of CD4+ T helper cells. PLoS ONE 7 e46615 PMID: 23029557
If you know of a relevant reference for GSK 2033, please let us know.
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Keywords: GSK 2033, supplier, GSK2033, Potent, LXR, antagonists, liver, x, receptors, LXR-like, Receptors, LXR-like, Receptors, Tocris Bioscience
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