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Potent LXR antagonist (pIC50 = 7.5). Enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. Cell permeable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 591.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||8.45 mL||42.25 mL||84.51 mL|
|1 mM||1.69 mL||8.45 mL||16.9 mL|
|2 mM||0.85 mL||4.23 mL||8.45 mL|
|10 mM||0.17 mL||0.85 mL||1.69 mL|
References are publications that support the biological activity of the product.
Zuercher et al (2010) Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J.Med.Chem. 53 3412 PMID: 20345102
Solt et al (2012) LXR-mediated inhibition of CD4+ T helper cells. PLoS ONE 7 e46615 PMID: 23029557
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Keywords: GSK 2033, GSK 2033 supplier, GSK2033, Potent, LXR, antagonists, liver, x, receptors, LXR-like, Receptors, 5694, Tocris Bioscience
1 Citation for GSK 2033
Citations are publications that use Tocris products. Selected citations for GSK 2033 include:
Bonney (2017) Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties. Eneuro 4 PMID: 28560318
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Literature in this Area
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